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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Ahmed, I.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2023Nanocomposite Hydrogel-Based Optical Fiber Probe for Continuous Glucose Sensing
- 2021Development and Characterization of Phosphate-Based Glass Coatings via Suspension High-Velocity Oxy-Fuel (SHVOF) Thermal Spray Processcitations
- 2021Antibacterial effect of titanium dioxide-doped phosphate glass microspheres filled total-etch dental adhesive on S. mutans biofilm
- 2020The effect of MgO/TiO2 on structural and crystallization behavior of near invert phosphate-based glassescitations
- 2019In vitro cellular testing of strontium/calcium substituted phosphate glass discs and microspheres shows potential for bone regenerationcitations
- 2019Correction: Ga and Ce ion-doped phosphate glass fibres with antibacterial properties and their composite for wound healing applications (Journal of Materials Chemistry B (2019) DOI: 10.1039/c9tb00820a)citations
- 2016Structural Disorder in Doped Zirconias, Part I: The Zr0.8Sc0.2-xYxO1.9 (0.0 <= x <= 0.2) Systemcitations
- 2016Oxygen vacancy ordering within anion-deficient Ceriacitations
- 2016In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerizationcitations
- 2014Phosphate-based glass fiber vs. bulk glass: Change in fiber optical response to probe in vitro glass reactivitycitations
- 2014Effect of Cellulose Nanowhiskers on Surface Morphology, Mechanical Properties, and Cell Adhesion of Melt-Drawn Polylactic Acid Fiberscitations
- 2014Surface modification of aramid fibres by graphene oxide nano-sheets for multiscale polymer compositescitations
- 2013Cytocompatibility, degradation, mechanical property retention and ion release profiles for phosphate glass fibre reinforced composite rodscitations
- 2013Cytocompatibility, degradation, mechanical property retention and ion release profiles for phosphate glass fibre reinforced composite rodscitations
- 2005Effect of iron on the surface, degradation and ion release properties of phosphate-based glass fibrescitations
- 2002Wear resistance of a high-nitrogen austenitic stainless steel coated with nitrogenated amorphous carbon filmscitations
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article
In vitro cellular testing of strontium/calcium substituted phosphate glass discs and microspheres shows potential for bone regeneration
Abstract
<p>Phosphate-based glasses (PBGs) are ideal materials for regenerative medicine strategies because their composition, degradation rates, and ion release profiles can easily be controlled. Strontium has previously been found to simultaneously affect bone resorption and deposition. Therefore, by combining the inherent properties of resorbable PBG and therapeutic activity of strontium, these glasses could be used as a delivery device of therapeutic factors for the treatment of orthopaedic diseases such as osteoporosis. This study shows the cytocompatibility and osteogenic potential of PBGs where CaO is gradually replaced by SrO in the near invert glass system 40P<sub>2</sub> O<sub>5</sub> ·(16-x)CaO·20Na<sub>2</sub> O·24MgO·xSrO (x = 0, 4, 8, 12, and 16 mol%). Direct seeding of MG63 cells onto glass discs showed no significant difference in cell metabolic activity and DNA amount measurement across the different formulations studied. Cell attachment and spreading was confirmed via scanning electron microscopy (SEM) imaging at Days 3 and 14. Alkaline phosphatase (ALP) activity was similarly maintained across the glass compositions. Follow-on studies explored the effect of each glass composition in microsphere conformation (size: 63-125 μm) on human mesenchymal stem cells (hMSCs) in 3D cultures, and analysis of cell metabolic activity and ALP activity showed no significant differences at Day 14 over the compositional range investigated, in line with the observations from MG63 cell culture studies. Environmental SEM and live cell imaging at Day 14 of hMSCs seeded on the microspheres showed cell attachment and colonisation of the microsphere surfaces, confirming these formulations as promising candidates for regenerative medicine strategies addressing compromised musculoskeletal/orthopaedic diseases.</p>