| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Oliveira, Ana L.
Universidade Católica Portuguesa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2022Adenosine-loaded silk fibroin aerogel particles for wound healing
- 2022Opening new avenues for bioceramicscitations
- 2021New prospects in skin regeneration and repair using nanophased hydroxyapatite embedded in collagen nanofiberscitations
- 2021High efficient strategy for the production of hydroxyapatite/silk sericin nanocompositescitations
- 2020Hydroxyapatite/sericin compositescitations
- 2020High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites
- 2020Hydroxyapatite/sericin composites:a simple synthesis route under near-physiological conditions of temperature and pH and preliminary study of the effect of sericin on the biomineralization processcitations
- 2019Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO2-based approachcitations
- 2019Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO 2 -based approachcitations
- 2018Combinatory approach for developing silk fibroin scaffolds for cartilage regenerationcitations
- 2017Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applicationscitations
- 2017Silk-based anisotropical 3D biotextiles for bone regenerationcitations
- 2017Core-shell silk hydrogels with spatially tuned conformations as drug-delivery systemcitations
- 2016Combinatory approach for developing silk fibroin-based scaffolds with hierarchical porosity and enhanced performance for cartilage tissue engineering applications
- 2013Evaluation of novel 3D architectures based on knitting technologies for engineering biological tissues
- 2012Aligned silk-based 3-D architectures for contact guidance in tissue engineeringcitations
- 2009Nucleation and growth of biomimetic apatite layers on 3D plotted biodegradable polymeric scaffoldscitations
- 2005Study of the influence of β-radiation on the properties and mineralization of different starch-based biomaterialscitations
- 2004Pre-mineralisation of starch/polycrapolactone bone tissue engineering scaffolds by a calcium-silicate-based processcitations
- 2003Biomimetic coating of starch based polymeric foams produced by a calcium silicate based methodologycitations
- 2003Bi-composite sandwich moldingscitations
- 2003Sodium silicate gel as a precursor for the in vitro nucleation and growth of a bone-like apatite coating in compact and porous polymeric structurescitations
- 2001Sodium silicate gel induced self-mineralization of different compact and porous polymeric structurescitations
Places of action
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article
Core-shell silk hydrogels with spatially tuned conformations as drug-delivery system
Abstract
Hydrogels of spatially controlled physicochemical properties are appealing platforms for tissue engineering and drug delivery. In this study, core-shell silk fibroin (SF) hydrogels of spatially controlled conformation were developed. The core-shell structure in the hydrogels was formed by means of soaking the preformed (enzymatically crosslinked) random coil SF hydrogels in methanol. When increasing the methanol treatment time from 1 to 10 min, the thickness of the shell layer can be tuned from about 200 to about 850 μm as measured in wet status. After lyophilization of the rehydrated core-shell hydrogels, the shell layer displayed compact morphology and the core layer presented porous structure, when observed by scanning electron microscopy. The conformation of the hydrogels was evaluated by Fourier transform infrared spectroscopy in wet status. The results revealed that the shell layer possessed dominant β-sheet conformation and the core layer maintained mainly random coil conformation. Enzymatic degradation data showed that the shell layers presented superior stability to the core layer. The mechanical analysis displayed that the compressive modulus of the core-shell hydrogels ranged from about 25 kPa to about 1.1 MPa by increasing the immersion time in methanol. When incorporated with albumin, the core-shell SF hydrogels demonstrated slower and more controllable release profiles compared with the non-treated hydrogel. These core-shell SF hydrogels of highly tuned properties are useful systems as drug-delivery system and may be applied as cartilage substitute.