| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Salih, Vehid
University of Plymouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (28/28 displayed)
- 2016Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3‐hydroxybutyrate) and micro‐fibrillated bacterial cellulosecitations
- 2016P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineeringcitations
- 2015Titanium phosphate glass microcarriers induce enhanced osteogenic cell proliferation and human mesenchymal stem cell protein expressioncitations
- 2012Titanium-containing bioactive phosphate glasses.citations
- 2012Osteochondral tissue engineering: scaffolds, stem cells and applications.citations
- 2012Structural characterization and physical properties of P2O5-CaO-Na2O-TiO2 glasses by Fourier transform infrared, Raman and solid-state magic angle spinning nuclear magnetic resonance spectroscopies.citations
- 2012Titanium phosphate glass microspheres for bone tissue engineering.citations
- 2012The enhanced modulation of key bone matrix components by modified Titanium implant surfaces.citations
- 2011Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.citations
- 2011In vitro evaluation of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with carbon nanotubes.citations
- 2011Ag-Doped Sol-Gel Derived Novel Composite Materials for Dental Applicationscitations
- 2011Effect of deposition parameters and post-deposition annealing on the morphology and cellular response of electrosprayed TiO2 films.citations
- 2010Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications.citations
- 2010<i>In vitro</i> studies on the influence of surface modification of Ni–Ti alloy on human bone cellscitations
- 2010Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: chemical, mechanical and biological considerations.citations
- 2010Chemical, modulus and cell attachment studies of reactive calcium phosphate filler-containing fast photo-curing, surface-degrading, polymeric bone adhesives.citations
- 2009Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility.citations
- 2009Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment.citations
- 2009Development of remineralizing, antibacterial dental materials.citations
- 2009In vitro biocompatibility of 45S5 Bioglass-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate).citations
- 2008Bioglass-derived glass-ceramic scaffolds: study of cell proliferation and scaffold degradation in vitro.citations
- 2008Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass composites.citations
- 2006Initial responses of human osteoblasts to sol-gel modified titanium with hydroxyapatite and titania composition.citations
- 2006Initial responses of human osteoblasts to sol–gel modified titanium with hydroxyapatite and titania composition
- 2005Biocompatible phosphate glass fibre scaffolds
- 2005Soluble phosphate glass fibres for repair of bone-ligament interface.citations
- 2004Physicochemical, mechanical, and biological properties of bone cements prepared with functionalized methacrylatescitations
- 2002The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system.citations
Places of action
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article
In vitro biocompatibility of 45S5 Bioglass-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate).
Abstract
The aim of this work was to study the in vitro biocompatibility of glass-ceramic scaffolds based on 45S5 Bioglass, using a human osteosarcoma cell line (HOS-TE85). The highly porous scaffolds were produced by the foam replication technique. Two different types of scaffolds with different porosities were analysed. They were coated with a biodegradable polymer, poly(3-hydroxybutyrate) (P(3HB)). The scaffold bioactivity was evaluated by soaking in a simulated body fluid (SBF) for different durations. Compression strength tests were performed before and after immersion in SBF. These experiments showed that the scaffolds are highly bioactive, as after a few days of immersion in SBF a hydroxyapatite-like layer was formed on the scaffold's surface. It was also observed that P(3HB)-coated samples exhibited higher values of compression strength than uncoated samples. Biocompatibility assessment was carried out by qualitative evaluation of cell morphology after different culture periods, using scanning electron microscopy, while cell proliferation was determined by using the AlamarBlue assay. Alkaline phosphatase (ALP) and osteocalcin (OC) assays were used as quantitative in vitro indicators of osteoblast function. Two different types of medium were used for ALP and OC tests: normal supplemented medium and osteogenic medium. HOS cells were seeded and cultured onto the scaffolds for up to 2 weeks. The AlamarBlue assay showed that cells were able to proliferate and grow on the scaffold surface. After 7 days in culture, the P(3HB)-coated samples had a higher number of cells on their surfaces than the uncoated samples. Regarding ALP- and OC-specific activity, no significant differences were found between samples with different pore sizes. All scaffolds containing osteogenic medium seemed to have a slightly higher level of ALP and OC concentration. These experiments confirmed that Bioglass/P(3HB) scaffolds have potential as osteoconductive tissue engineering substrates for maintenance and normal functioning of bone tissue.