| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Niemeyer, Christof M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024Engineering Phi29‐DNAP Variants for Customized DNA Hydrogel Materials
- 2024Quantitative Characterization of RCA‐based DNA Hydrogels – Towards Rational Designcitations
- 2024Solvent‐Independent 3D Printing of Organogelscitations
- 2024Micromechanical Indentation Platform for Rapid Analysis of Viscoelastic Biomolecular Hydrogelscitations
- 2023Accurate quantification of DNA content in DNA hydrogels prepared by rolling circle amplificationcitations
- 2022Systematic evaluation of agarose- and agar-based bioinks for extrusion-based bioprinting of enzymatically active hydrogelscitations
- 2021Formulation of DNA Nanocomposites: Towards Functional Materials for Protein Expressioncitations
- 2020Postsynthetic Functionalization of DNA‐Nanocomposites with Proteins Yields Bioinstructive Matrices for Cell Culture Applicationscitations
- 2019Bottom‐Up Assembly of DNA–Silica Nanocomposites into Micrometer‐Sized Hollow Spherescitations
- 2017DNA-SMARTcitations
Places of action
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article
Micromechanical Indentation Platform for Rapid Analysis of Viscoelastic Biomolecular Hydrogels
Abstract
The advent of biomedical applications of soft bioinspired materials hasentailed an increasing demand for streamlined and expedient characterizationmethods meant for both research and quality control objectives. Here, a novelmeasurement system for the characterization of biological hydrogels withvolumes as low as 75 μL was developed. The system is based on anindentation platform equipped with micrometer drive actuators that allow thedetermination of both the fracture points and Young’s moduli of relatively stiffpolymers, including agarose, as well as the measurements of viscosity forexceptionally soft and viscous hydrogels, such as DNA hydrogels. Thesensitivity of the method allows differentiation between DNA hydrogelsproduced by rolling circle amplification based on different template sequencesand synthesis protocols. In addition, the polymerization kinetics of thehydrogels can be determined by time-resolved measurements, and theapparent viscosities of even more complex DNA-based nanocomposites canbe measured. The platform presented here thus offers the possibility tocharacterize a broad variety of soft biomaterials in a targeted, fast, andcost-effective manner, holding promises for applications in fundamentalmaterials science and ensuring reproducibility in the handling of complexmaterials.