| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Werner, Carsten
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (45/45 displayed)
- 202375 years of polymer research in Dresden
- 2023Discriminant Principal Component Analysis of ToF-SIMS Spectra for Deciphering Compositional Differences of MSC-Secreted Extracellular Matricescitations
- 2023Hydrogel-Coated Nanonet-Based Field-Effect Transistors for SARS-CoV-2 Spike Protein Detection in High Ionic Strength Samples
- 2023Dynamic matrices with DNA-encoded viscoelasticity for cell and organoid culturecitations
- 2022Microenvironment-mediated cancer dormancy: Insights from metastability theorycitations
- 2022Real-Time Monitoring of Blood Parameters in the Intensive Care Unit: State-of-the-Art and Perspectivescitations
- 2021Hemocompatible Electrochemical Sensors for Continuous Monitoring of Blood Parameterscitations
- 2021Bioresponsive starPEG-heparin hydrogel coatings on vascular stents for enhanced hemocompatibilitycitations
- 2020Protein Component of Oyster Glycogen Nanoparticlescitations
- 2019Highly conductive, stretchable, and cell‐adhesive hydrogel by nanoclay dopingcitations
- 2019Impact of oral astringent stimuli on surface charge and morphology of the protein-rich pellicle at the tooth–saliva interphasecitations
- 2019Fabrication of multifunctional titanium surfaces by producing hierarchical surface patterns using laser based ablation methodscitations
- 2019Temperature-Induced Mechanomodulation of Interpenetrating Networks of Star Poly(ethylene glycol)-Heparin and Poly(N-isopropylacrylamide)citations
- 2019Springtail-inspired triangular laser-induced surface textures on metals using mhz ultrashort pulsescitations
- 2018Analyzing the antiseptic capacity of silver-functionalized poly(ethylene glycol)-heparin hydrogels after human whole blood exposurecitations
- 2017Solvent-assisted micromolding of biohybrid hydrogels to maintain human hematopoietic stem and progenitor cells ex vivocitations
- 2017Cell-instructive starPEG-heparin-collagen composite matricescitations
- 2017Forbidden Chemistrycitations
- 2017Macromolecular crowding for tailoring tissue-derived fibrillated matricescitations
- 2016A hyperbranched dopamine-containing PEG-based polymer for the inhibition of α-synuclein fibrillationcitations
- 2015Thermo-responsive cell culture carriers based on poly(vinyl methyl ether) - The effect of biomolecular ligands to balance cell adhesion and stimulated detachment
- 2015Thermo-responsive cell culture carriers based on poly(Vinyl Methyl ether) - the effect of biomolecular ligands to balance cell adhesion and stimulated detachment.citations
- 2014Influence of Individual Phospholipids on the Physical Properties of Oil-Based Suspensionscitations
- 2013The impact of lecithin on rheology, sedimentation and particle interactions in oil-based dispersionscitations
- 2013Permanent surface modification by electron-beam-induced grafting of hydrophilic polymers to PVDF membranescitations
- 2013On the use of electrokinetics for unraveling charging and structure of soft planar polymer filmscitations
- 2013ECM modulated early kidney development in embryonic organ culturecitations
- 2012Surface modification of cell culture carrierscitations
- 2012Polymeric biomaterials for stem cell bioengineeringcitations
- 2011Biokompatible und bioaktive polymere Beschichtungencitations
- 2011Immobilization of Bacillus licheniformis α-amylase onto reactive polymer filmscitations
- 2011Enzyme immobilization on reactive polymer filmscitations
- 2011Modulating Biofunctional starPEG Heparin Hydrogels by Varying Size and Ratio of the Constituentscitations
- 2011Electron beam immobilization of functionalized poly(vinyl methyl ether) thin films on polymer surfaces - Towards stimuli responsive coatings for biomedical purposescitations
- 2011Enzymes for antifouling strategiescitations
- 2010The role of the interplay between polymer architecture and bacterial surface properties on the microbial adhesion to polyoxazoline-based ultrathin filmscitations
- 2010Studying the influence of chemical structure on the surface properties of polymer filmscitations
- 2010Hydroxide and hydronium ion adsorption - A surveycitations
- 2009Charging and structure of zwitterionic supported bilayer lipid membranes studied by streaming current measurements, fluorescence microscopy, and attenuated total reflection Fourier transform infrared spectroscopycitations
- 2009Temperature dependent physicochemical properties of poly(N- isopropylacrylamide-co-N-(1-phenylethyl) acrylamide) thin filmscitations
- 2009Electrostatic stretching of grafted maleic acid copolymer chainscitations
- 2004In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivativecitations
- 2002Characterization of oxide layers on Ti6Al4V and titanium by streaming potential and streaming current measurementscitations
- 2001Electrokinetic Measurements Reveal Interfacial Charge at Polymer Films Caused by Simple Electrolyte Ionscitations
- 2000Analiza povrsine vlaken z mikroskopijo atomskih sil (AFM)
Places of action
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article
Discriminant Principal Component Analysis of ToF-SIMS Spectra for Deciphering Compositional Differences of MSC-Secreted Extracellular Matrices
Abstract
<p>Identifying characteristic extracellular matrix (ECM) variants is a key challenge in mechanistic biology, bioengineering, and medical diagnostics. The reported study demonstrates the potential of time-of-flight secondary ion mass spectrometry (ToF-SIMS) to detect subtle differences between human mesenchymal stromal cell (MSC)-secreted ECM types as induced by exogenous stimulation or emerging pathology. ToF-SIMS spectra of decellularized ECM samples are evaluated by discriminant principal component analysis (DPCA), an advanced multivariate analysis technique, to decipher characteristic compositional features. To establish the approach, signatures of major ECM proteins are determined from samples of pre-defined mixtures. Based on that, sets of ECM variants produced by MSCs in vitro are analyzed. Differences in the content of collagen, fibronectin, and laminin in the ECM resulting from the combined supplementation of MSC cultures with polymers that induce macromolecular crowding and with ascorbic acid are detected from the DPCA of ToF-SIMS spectra. The results are verified by immunostaining. Finally, the comparative ToF-SIMS analysis of ECM produced by MSCs of healthy donors and patients suffering from myelodysplastic syndrome display the potential of the novel methodology to reveal disease-associated alterations of the ECM composition.</p>