| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Radulescu, Aurel
Forschungszentrum Jülich
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (29/29 displayed)
- 2024Advances in Small Angle Neutron Scattering on Polysaccharide Materialscitations
- 2023Structure of Single-Chain Nanoparticles under Crowding Conditions: A Random Phase Approximation Approachcitations
- 2023Extended <i>Q</i>-range small-angle neutron scattering to understand the morphology of proton-exchange membranes: the case of the functionalized syndiotactic-polystyrene model systemcitations
- 2023Extended Q -range small-angle neutron scattering to understand the morphology of proton-exchange membranes: the case of the functionalized syndiotactic-polystyrene model systemcitations
- 2023Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulationcitations
- 2022Influence of chain length of gradient and block copoly(2-oxazoline)s on self-assembly and drug encapsulationcitations
- 2022Influence of Chain Length of Gradient and Block Copoly(2-oxazoline)s on Self-Assembly and Drug Encapsulationcitations
- 2022Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulationcitations
- 2021Physicochemical approach to understanding the structure, conformation, and activity of mannan polysaccharidescitations
- 2021Poloxamine/D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles and gels: Morphology, loading capacity and skin drug permeabilitycitations
- 2021Poloxamine/D-α-Tocopheryl polyethylene glycol succinate (TPGS) mixed micelles and gels:Morphology, loading capacity and skin drug permeabilitycitations
- 2021Morphology, gelation and cytotoxicity evaluation of D-α-Tocopheryl polyethylene glycol succinate (TPGS) – Tetronic mixed micellescitations
- 2021Chain-End Effects on Supramolecular Poly(ethylene glycol) Polymerscitations
- 2021Synthesis and Characterization of 4‐Vinylimidazolium/Styrene‐Cografted Anion‐Conducting Electrolyte Membranescitations
- 2020The Effects of Temperature and Humidity on the Microstructure of Sulfonated Syndiotactic–polystyrene Ionic Membranescitations
- 2020Revealing the Aggregation Mechanism, Structure, and Internal Dynamics of Poly(vinyl alcohol) Microgel Prepared through Liquid–Liquid Phase Separationcitations
- 2019All-In-One “Schizophrenic” Self-Assembly of Orthogonally Tuned Thermoresponsive Diblock Copolymerscitations
- 2019The Multilevel Structure of Sulfonated Syndiotactic-Polystyrene Model Polyelectrolyte Membranes Resolved by Extended Q-Range Contrast Variation SANScitations
- 2019Inner structure and dynamics of microgels with low and medium crosslinker content prepared via surfactant-free precipitation polymerization and continuous monomer feeding approach
- 2018Structure and morphology of model polymer electrolyte membranes based on sulfonated syndiotactic-polystyrene in the δ co-crystalline phase resolved by small-angle neutron scatteringcitations
- 2018Poly-ethylene-vinyl alcohol microgels prepared through salting out: Rationalizing the aggregation process and tuning the microstructural propertiescitations
- 2018Small angle neutron scattering study on the morphology of imidazolium-based grafted anion-conducting fuel cell membranescitations
- 2018Relevance of Internal Friction and Structural Constraints for the Dynamics of Denatured Bovine Serum Albumincitations
- 2017Block and gradient copoly(2-oxazoline) micelles: strikingly different on the insidecitations
- 2015Selective tuning of the self-assembly and gelation of a hydrophilic poloxamine by cyclodextrinscitations
- 2015Modulating the self-assembly of amphiphilic X-shaped block copolymers with cyclodextrins:Structure and mechanismscitations
- 2014Inner Structure of Adsorbed Ionic Microgel Particlescitations
- 2013A microscopic view on the large scale chain dynamics in nanocomposites with attractive interactionscitations
- 2013Studying Model samples to understand mechanical Properties of filled Elastomers
Places of action
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article
Influence of Chain Length of Gradient and Block Copoly(2‐oxazoline)s on Self‐Assembly and Drug Encapsulation
Abstract
<jats:title>Abstract</jats:title><jats:p>Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one‐step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in‐depth analysis is provided of micelles based on amphiphilic gradient poly(2‐oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock copolymer micelles. Size, morphology, and stability of self‐assembled nanoparticles, loading of hydrophobic drug curcumin, as well as cytotoxicities of the prepared nanoformulations are examined using copoly(2‐oxazoline)s with varying chain lengths and comonomer ratios. In addition to several interesting differences between the two copolymer architecture classes, such as more compact self‐assembled structures with faster exchange dynamics for the gradient copolymers, it is concluded that gradient copolymers provide stable curcumin nanoformulations with comparable drug loadings to block copolymer systems and benefit from more straightforward copolymer synthesis. The study demonstrates the potential of amphiphilic gradient copolymers as a versatile platform for the synthesis of new polymer therapeutics.</jats:p>