| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Koynov, Kaloian
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024Pressure Changes Across a Membrane Formed by Coacervation of Oppositely Charged Polymer-Surfactant Systemscitations
- 2023Complex Structures Made Simple – Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Delivery ; ENEngelskEnglishComplex Structures Made Simple – Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Deliverycitations
- 2023Complex Structures Made Simple - Continuous Flow Production of Core Cross-Linked Polymeric Micelles for Paclitaxel Pro-Drug-Deliverycitations
- 2022Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patchescitations
- 2022Temperature Controlled Mechanical Reinforcement of Polyacrylate Films Containing Nematic Liquid Crystalscitations
- 2021Macroscopic Viscosity of Polymer Solutions from the Nanoscale Analysiscitations
- 2019Nanotopography-Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activationcitations
- 2018FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticlescitations
- 2017Dynamic Heterogeneity in Random Copolymers of Polymethacrylates Bearing Different Polyhedral Oligomeric Silsesquioxane Moieties (POSS)citations
- 2015Polymethacrylates with polyhedral oligomeric silsesquioxane (POSS) moieties: Influence of spacer length on packing, thermodynamics, and dynamicscitations
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article
Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches
Abstract
<p>Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.</p>