| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Macgregor, Melanie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Electrochemical behavior of oxazoline-based plasma polymers for biosensing applicationscitations
- 2022Organic Monolayers on Si(211) for Triboelectricity Generationcitations
- 2022Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patchescitations
- 2021Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensorscitations
- 2019Nanotopography-Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activationcitations
- 2019Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolinescitations
- 2018Binding of Nanoparticles to Aminated Plasma Polymer Surfaces is Controlled by Primary Amine Density and Solution pHcitations
- 2016A comparative assessment of nanoparticulate and metallic silver coated dressingscitations
- 2016Plasma deposition of organic polymer films for solar cell applicationscitations
- 2015Properties and reactivity of polyoxazoline plasma polymer filmscitations
Places of action
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article
Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches
Abstract
<p>Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.</p>