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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhang, Yan
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2023Recyclable 3D‐Printed Aqueous Lithium‐Ion Batterycitations
- 2023Controlling Charge Transport in 2D Conductive MOFs─The Role of Nitrogen-Rich Ligands and Chemical Functionality.citations
- 2022Interface Stability between Na3Zr2Si2PO12 Solid Electrolyte and Sodium Metal Anode for Quasi-Solid-State Sodium Batterycitations
- 2022Ultrasonic Transducers made from Freeze-Cast Porous Piezoceramicscitations
- 2021Piezoelectric tunability and topological insulator transition in a GaN/InN/GaN quantum-well devicecitations
- 2021Patch test–relevant concentrations of metal salts cause localized cytotoxicity, including apoptosis, in skin ex vivocitations
- 2021Correlation between dielectric, mechanical properties and electromechanical performance of functionalized graphene / polyurethane nanocompositescitations
- 2020Self-healing dielectric elastomers for damage-Tolerant actuation and energy harvestingcitations
- 2020Harnessing Plasticity in an Amine-Borane as a Piezoelectric and Pyroelectric Flexible Filmcitations
- 2019Piezoelectric performance of PZT-based materials with aligned porosity::experiment and modellingcitations
- 2019Ice-templated poly(vinylidene fluoride) ferroelectretscitations
- 2019Piezoelectric performance of PZT-based materials with aligned porosity:citations
- 20181-3-Type Composites Based on Ferroelectrics:Electromechanical Coupling, Figures of Merit, and Piezotechnical Energy-Harvesting Applicationscitations
- 2018Understanding the effect of porosity on the polarisation-field response of ferroelectric materialscitations
- 20181-3-Type Composites Based on Ferroelectricscitations
- 2018Ice-templated poly(vinylidene fluoride) ferroelectretscitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
Places of action
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article
Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Delivery
Abstract
Composite coatings are considered as a promising approach to tailor the biointerface between a (implantable) biomaterial and adhering/surrounding cells or tissue. In this context, composite coatings assembled using a polymer matrix with embedded drug deposits are particularly interesting due to the advanced control over cargo loading, retention and release. Herein, we compare the assembly of such films consisting of different types of liposomes as subunits within a polymer film using either poly(dopamine) (PDA) or for the first time, tannic acid (TA) as an alternative. It is found that TA is a suitable capping layer for liposome-coated substrates which allows for post-modification. The composite coatings are suitable to support hepatocyte adhesion depending on the terminating polymer layer. Furthermore, incorporation of cholesterol-dopamine (Ch-DA) conjugates into the zwitterionic liposomes increases the numbers of deposited subunits. Finally, cytotoxic paclitaxel is loaded into the liposomes and delivered to the adhering hepatocytes. The capability to reduce hepatocyte adhesion to the composite coating varied. Composite coatings consisting of negatively charged liposomes with Ch-DA and a PDA capping layer are found to be most efficient after 24 h and 48 h. Taken together, this fundamental comparison of different composite coatings illustrates the excellent opportunities to engineer the biological response towards the application in mind.