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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Salih, Vehid
University of Plymouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (28/28 displayed)
- 2016Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3‐hydroxybutyrate) and micro‐fibrillated bacterial cellulosecitations
- 2016P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineeringcitations
- 2015Titanium phosphate glass microcarriers induce enhanced osteogenic cell proliferation and human mesenchymal stem cell protein expressioncitations
- 2012Titanium-containing bioactive phosphate glasses.citations
- 2012Osteochondral tissue engineering: scaffolds, stem cells and applications.citations
- 2012Structural characterization and physical properties of P2O5-CaO-Na2O-TiO2 glasses by Fourier transform infrared, Raman and solid-state magic angle spinning nuclear magnetic resonance spectroscopies.citations
- 2012Titanium phosphate glass microspheres for bone tissue engineering.citations
- 2012The enhanced modulation of key bone matrix components by modified Titanium implant surfaces.citations
- 2011Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.citations
- 2011In vitro evaluation of 45S5 Bioglass®-derived glass-ceramic scaffolds coated with carbon nanotubes.citations
- 2011Ag-Doped Sol-Gel Derived Novel Composite Materials for Dental Applicationscitations
- 2011Effect of deposition parameters and post-deposition annealing on the morphology and cellular response of electrosprayed TiO2 films.citations
- 2010Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications.citations
- 2010<i>In vitro</i> studies on the influence of surface modification of Ni–Ti alloy on human bone cellscitations
- 2010Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: chemical, mechanical and biological considerations.citations
- 2010Chemical, modulus and cell attachment studies of reactive calcium phosphate filler-containing fast photo-curing, surface-degrading, polymeric bone adhesives.citations
- 2009Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility.citations
- 2009Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment.citations
- 2009Development of remineralizing, antibacterial dental materials.citations
- 2009In vitro biocompatibility of 45S5 Bioglass-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate).citations
- 2008Bioglass-derived glass-ceramic scaffolds: study of cell proliferation and scaffold degradation in vitro.citations
- 2008Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass composites.citations
- 2006Initial responses of human osteoblasts to sol-gel modified titanium with hydroxyapatite and titania composition.citations
- 2006Initial responses of human osteoblasts to sol–gel modified titanium with hydroxyapatite and titania composition
- 2005Biocompatible phosphate glass fibre scaffolds
- 2005Soluble phosphate glass fibres for repair of bone-ligament interface.citations
- 2004Physicochemical, mechanical, and biological properties of bone cements prepared with functionalized methacrylatescitations
- 2002The effect of MgO on the solubility behavior and cell proliferation in a quaternary soluble phosphate based glass system.citations
Places of action
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article
Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3‐hydroxybutyrate) and micro‐fibrillated bacterial cellulose
Abstract
Cartilage tissue engineering is an emerging therapeutic strategy that aims to regenerate damaged cartilage caused by disease, trauma, ageing or developmental disorder. Since cartilage lacks regenerative capabilities, it is essential to develop approaches that deliver the appropriate cells, biomaterials and signalling factors to the defect site. Materials and fabrication technologies are therefore critically important for cartilage tissue engineering in designing temporary, artificial extracellular matrices (scaffolds), which support 3D cartilage formation. Hence, this work aimed to investigate the use of poly(3-hydroxybutyrate)/microfibrillated bacterial cellulose (P(3HB)/MFC) composites as 3D-scaffolds for potential application in cartilage tissue engineering. The compression moulding/particulate leaching technique employed in the study resulted in good dispersion and a strong adhesion between the MFC and the P(3HB) matrix. Furthermore, the composite scaffold produced displayed better mechanical properties than the neat P(3HB) scaffold. On addition of 10, 20, 30 and 40 wt% MFC to the P(3HB) matrix, the compressive modulus was found to have increased by 35%, 37%, 64% and 124%, while the compression yield strength increased by 95%, 97%, 98% and 102% respectively with respect to neat P(3HB). Both cell attachment and proliferation were found to be optimal on the polymer-based 3D composite scaffolds produced, indicating a non-toxic and highly compatible surface for the adhesion and proliferation of mouse chondrogenic ATDC5 cells. The large pores sizes (60-83 mu m) in the 3D scaffold allowed infiltration and migration of ATDC5 cells deep into the porous network of the scaffold material. Overall this work confirmed the potential of P(3HB)/MFC composites as novel materials in cartilage tissue engineering.