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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Ali, M. A. |
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| Rančić, M. |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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Fages, Jacques
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2023Foaming of PLA biocomposites by supercritical CO2 assisted extrusion process
- 2023Foaming of PLA biocomposites by supercritical CO2 assisted extrusion process
- 2021PLA-based biocomposites foaming by supercritical CO2 assisted batch process
- 2021PLA-based biocomposites foaming by supercritical CO2 assisted batch process
- 2021Blending and foaming thermoplastic starch with poly (lactic acid) by CO 2 ‐aided hot melt extrusioncitations
- 2021Foaming of PLA-based Biocomposites by Supercritical CO2 Assisted Batch Process : Effect of Processing and Cellulose Fibres on Foam Microstructure
- 2021Foaming of PLA-based Biocomposites by Supercritical CO2 Assisted Batch Process : Effect of Processing and Cellulose Fibres on Foam Microstructure
- 2017Modelling Nucleation and Cell Size During the Continuous Process of Extrusion Assisted by Supercritical CO 2
- 2016Characterisation of natural fibre reinforced PLA foams prepared by supercritical CO 2 assisted extrusioncitations
- 2012Use of supercritical CO2-aided and conventional melt extrusion for enhancing the dissolution rate of an active pharmaceutical ingredientcitations
- 2011On-line rheological measurement of a binary mixture polymer/sc-CO2 in an extruder
- 2011New challenges in polymer foaming: A review of extrusion processes assisted by supercritical carbon dioxidecitations
- 2010Biosourced polymer foam production using a (SC CO2) -assisted extrusion process
- 2008A new supercritical co-injection process to coat microparticlescitations
- 2008Application of the Markov chain theory for modelling residence time distribution in a single screw extruder
- 2007Microencapsulation by a solvent-free supercritical fluid process : use of density, calorimetric, and size analysis to quantify and qualify the coatingcitations
- 2004A new test for cleaning efficiency assessment of cleaners for hard surfacescitations
- 2004Supercritical carbon dioxide : an efficient tool for the production of ultra-fine particles for the food and pharmaceutical industries
- 2002Extraction and precipitation particle coating using supercritical CO2citations
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article
Use of supercritical CO2-aided and conventional melt extrusion for enhancing the dissolution rate of an active pharmaceutical ingredient
Abstract
Dispersing at the molecular level a drug in a polymer matrix is a major challenge to be addressed by the pharmaceutical industry to enhance its bioavailability or to control its release. Melt extrusion and supercritical CO2-aided melt extrusion of solid pharmaceutical formulations were performed to enhance the dissolution rate of carvedilol, taken as a model of poorly soluble drug. The presence of the drug improved the processability of the polyacrylate matrix (Eudragit E) through its plasticizing effect. The supercritical method was found gentle compared with melt extrusion owing to the shorter residence time and lower processing temperature and melt viscosity. No traces of decomposition of the drug could be detected after the supercritical extrusion process based on capillary electrophoresis results. This extrusion process resulted in effective homogenization of the components and amorphization of the drug according to Raman mapping, Fourier transform infrared spectrometry, X-ray diffraction, and polarized light microscopy. The kinetics of dissolution can be dramatically improved. Copyright (c) 2011 John Wiley & Sons, Ltd.