| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Sinkus, Ralph
King's College London
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic <scp>MR</scp> Elastographycitations
- 2020On the origin of frequency power-law for tissue mechanics in elastography
- 2019Magnetic resonance elastography of skeletal muscle deep tissue injurycitations
- 2019Magnetic resonance elastography of skeletal muscle deep tissue injury
- 2015MR Elastography Can Be Used to Measure Brain Stiffness Changes as a Result of Altered Cranial Venous Drainage During Jugular Compressioncitations
- 2014Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography.citations
- 2014Viscoelastic parameters for quantifying liver fibrosiscitations
- 2013Measuring anisotropic muscle stiffness properties using elastographycitations
- 2013Curl-based Finite Element Reconstruction of the Shear Modulus Without Assuming Local Homogeneitycitations
- 2011Using static preload with magnetic resonance elastography to estimate large strain viscoelastic properties of bovine livercitations
- 2011Viscoelastic properties of the tongue and soft palate using MR elastographycitations
- 2009Magnetic resonance elastography in the liver at 3 Tesla using a second harmonic approachcitations
- 2008In vivo brain viscoelastic properties measured by magnetic resonance elastographycitations
- 2007MR elastography of breast lesionscitations
- 2005Imaging anisotropic and viscous properties of breast tissue by magnetic resonance-elastographycitations
Places of action
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article
Magnetic resonance elastography of skeletal muscle deep tissue injury
Abstract
<p>The current state-of-the-art diagnosis method for deep tissue injury in muscle, a subcategory of pressure ulcers, is palpation. It is recognized that deep tissue injury is frequently preceded by altered biomechanical properties. A quantitative understanding of the changes in biomechanical properties preceding and during deep tissue injury development is therefore highly desired. In this paper we quantified the spatial–temporal changes in mechanical properties upon damage development and recovery in a rat model of deep tissue injury. Deep tissue injury was induced in nine rats by two hours of sustained deformation of the tibialis anterior muscle. Magnetic resonance elastography (MRE), T<sub>2</sub>-weighted, and T<sub>2</sub>-mapping measurements were performed before, directly after indentation, and at several timepoints during a 14-day follow-up. The results revealed a local hotspot of elevated shear modulus (from 3.30 ± 0.14 kPa before to 4.22 ± 0.90 kPa after) near the center of deformation at Day 0, whereas the T<sub>2</sub>was elevated in a larger area. During recovery there was a clear difference in the time course of the shear modulus and T<sub>2</sub>. Whereas T<sub>2</sub>showed a gradual normalization towards baseline, the shear modulus dropped below baseline from Day 3 up to Day 10 (from 3.29 ± 0.07 kPa before to 2.68 ± 0.23 kPa at Day 10, P < 0.001), followed by a normalization at Day 14. In conclusion, we found an initial increase in shear modulus directly after two hours of damage-inducing deformation, which was followed by decreased shear modulus from Day 3 up to Day 10, and subsequent normalization. The lower shear modulus originates from the moderate to severe degeneration of the muscle. MRE stiffness values were affected in a smaller area as compared with T<sub>2</sub>. Since T<sub>2</sub>elevation is related to edema, distributing along the muscle fibers proximally and distally from the injury, we suggest that MRE is more specific than T<sub>2</sub>for localization of the actual damaged area.</p>