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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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Kamel, Ihab R.
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article
Multicenter, multivendor validation of liver quantitative susceptibility mapping in patients with iron overload at 1.5T and 3T.
Abstract
PURPOSE: To evaluate the repeatability and reproducibility of QSM of the liver via single breath-hold chemical shift-encoded MRI at both 1.5T and 3T in a multicenter, multivendor study in subjects with iron overload.METHODS: This prospective study included four academic medical centers with three different MRI vendors at 1.5T and 3T. Subjects with known or suspected liver iron overload underwent multi-echo spoiled gradient-recalled-echo scans at each field strength. A subset received repeatability testing at either 1.5T or 3T. Susceptibility andR 2 *{{R}}_2^maps were reconstructed from the multi-echo images and analyzed at a single center. QSM-measured susceptibility was compared withR 2 *{{R}}_2^and a commercial R2-based liver iron concentration method across centers and field strengths using linear regression and F-tests on the intercept and slope. Field-strength reproducibility and test/retest repeatability were evaluated using Bland-Altman analysis.RESULTS: A total of 155/80 data sets (test/retest) were available at 1.5T, and 159/70 data sets (test/retest) were available at 3T. Calibrations across sites were reproducible, with some variability (e.g., susceptibility slope with liver iron concentration ranged from 0.102 to 0.123g/[mg·ppm] across centers at 1.5T). Field strength reproducibility was good (concordance correlation coefficient=0.862), and test/retest repeatability was excellent (intraclass correlation coefficient=0.951).CONCLUSION: QSM as an imaging biomarker of liver iron overload is feasible and repeatable across centers and MR vendors. It may be complementary withR 2 *{{R}}_2^as they are obtained from the same acquisition. Although good reproducibility was observed, liver QSM may benefit from standardization of acquisition parameters. Overall, QSM is a promising method for liver iron quantification.