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Mazur, Karolina
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article
The Effect of Antibacterial Particle Incorporation on the Mechanical Properties, Biodegradability, and Biocompatibility of PLA and PHBV Composites
Abstract
The composites based on polylactide (PLA) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with the addition of antibacterial particles: silver(Ag) and copper oxide (CuO) are characterized. Basic mechanical propertiesand biodegradation processes, as well as biocompatibility of materials withhuman cells are determined. The addition of Ag or CuO to the polymers donot significantly affect their mechanical properties, flammability, or biodegradationrate. However, several differences between the base materials areobserved. PLA-based composites have higher tensile and impact strengthvalues, while PHBV-based ones have a higher modulus of elasticity, as well asbetter mechanical properties at elevated temperatures. Concerning biocompatibility,each of the tested materials support the growth of fibroblasts overtime, although large differences are observed in the initial cell attachment.The analysis of hydrolytic degradation effects on the structure of materialsshows that PHBV degrades much faster than PLA. The results of this studyconfirm the good potential of the investigated biodegradable polymer compositeswith antibacterial particles for future biomedical applications.