| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Luxenhofer, Robert
University of Helsinki
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2025Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusioncitations
- 2024Amorphous solid dispersions of amphiphilic polymer excipients and indomethacin prepared by hot melt extrusioncitations
- 2024Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor Systemcitations
- 2023Investigation of cationic ring-opening polymerization of 2-oxazolines in the "green" solvent dihydrolevoglucosenonecitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline)citations
- 2021From Thermogelling Hydrogels toward Functional Bioinkscitations
- 2021Melt electrowriting of poly(vinylidene difluoride) using a heated collectorcitations
- 2021Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline) : synthesis, characterization and cytotoxicitycitations
- 2021Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inkscitations
- 2021From Thermogelling Hydrogels toward Functional Bioinks : Controlled Modification and Cytocompatible Crosslinkingcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N-propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline): synthesis, characterization and cytotoxicitycitations
- 2021Think Beyond the Core : Impact of the Hydrophilic Corona on Drug Solubilization Using Polymer Micellescitations
- 2021Freeform direct laser writing of versatile topological 3D scaffolds enabled by intrinsic support hydrogelcitations
- 2021Poly(2-ethyl-2-oxazoline-co-N -propylethylene imine)s by controlled partial reduction of poly(2-ethyl-2-oxazoline): Synthesis, characterization and cytotoxicitycitations
- 2021Development of a 3D printable and highly stretchable ternary organic–inorganic nanocomposite hydrogelcitations
- 2020Think Beyond the Corecitations
- 2020Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2020Probing the Complex Loading-Dependent Structural Changes in Ultrahigh Drug-Loaded Polymer Micelles by Small-Angle Neutron Scatteringcitations
- 2019Silanization of silica nanoparticles and their processing as nanostructured micro-raspberry powders - a route to control the mechanical properties of isoprene rubber compositescitations
- 2018Colloidal core-satellite supraparticles via preprogramed burst of nanostructured micro-raspberry particlescitations
- 2017Burstable nanostructured micro-raspberries: Towards redispersible nanoparticles from dry powderscitations
- 2011Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphilescitations
Places of action
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article
From Thermogelling Hydrogels toward Functional Bioinks
Abstract
<p>Hydrogels are key components in bioink formulations to ensure printability and stability in biofabrication. In this study, a well-known Diels-Alder two-step post-polymerization modification approach is introduced into thermogelling diblock copolymers, comprising poly(2-methyl-2-oxazoline) and thermoresponsive poly(2-n-propyl-2-oxazine). The diblock copolymers are partially hydrolyzed and subsequently modified by acid/amine coupling with furan and maleimide moieties. While the thermogelling and shear-thinning properties allow excellent printability, trigger-less cell-friendly Diels-Alder click-chemistry yields long-term shape-fidelity. The introduced platform enables easy incorporation of cell-binding moieties (RGD-peptide) for cellular interaction. The hydrogel is functionalized with RGD-peptides using thiol-maleimide chemistry and cell proliferation as well as morphology of fibroblasts seeded on top of the hydrogels confirm the cell adhesion facilitated by the peptides. Finally, bioink formulations are tested for biocompatibility by incorporating fibroblasts homogenously inside the polymer solution pre-printing. After the printing and crosslinking process good cytocompatibility is confirmed. The established bioink system combines a two-step approach by physical precursor gelation followed by an additional chemical stabilization, offering a broad versatility for further biomechanical adaptation or bioresponsive peptide modification.</p>