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Fernandes, Alexandra
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Publications (7/7 displayed)
- 2023Chitin-Glucan Complex Hydrogelscitations
- 2023Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPolcitations
- 2022Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NNʹO] ligandscitations
- 2019Antiproliferative activity of heterometallic sodium and potassium-dioxidovanadium(V) polymerscitations
- 2019Structural characterization and biological properties of silver(I) tris(pyrazolyl)methane sulfonatecitations
- 2015POxylated Polyurea Dendrimerscitations
- 2015A value-added exopolysaccharide as a coating agent for MRI nanoprobescitations
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article
POxylated Polyurea Dendrimers
Abstract
<p>The design and preparation of highly efficient drug delivery platforms using green methodologies is at the forefront of nanotherapeutics research. POxylated polyurea dendrimers are efficiently synthesized using a supercritical-assisted polymerization in carbon dioxide. These fluorescent, pH-responsive and water-soluble core-shell smart nanocarriers show low toxicity in terms of cell viability and absence of glutathione depletion, two of the major side effect limitations of current vectors. The materials are also found to act as good transfection agents, through a mechanism involving an endosomal pathway, being able to reduce 100-fold the IC50 of paclitaxel.</p>