| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Genina, Natalja
University of Copenhagen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2023Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tablets ; ENEngelskEnglishImpact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tabletscitations
- 2023Impact of Drug Load and Polymer Molecular Weight on the 3D Microstructure of Printed Tabletscitations
- 2023Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Productscitations
- 2021Toward a Design for Flowable and Extensible Ionomers: An Example of Diamine-Neutralized Entangled Poly(styrene-co-4-vinylbenzoic acid) Ionomer Meltscitations
- 2020Linear Viscoelastic and Nonlinear Extensional Rheology of Diamine Neutralized Entangled Poly(styrene-co-4-vinylbenzoic acid) Ionomer Melts
- 2020Linear Viscoelastic and Nonlinear Extensional Rheology of Diamine Neutralized Entangled Poly(styrene-co-4-vinylbenzoic acid) Ionomer Melts
- 2019Roadmap to 3D printed oral pharmaceutical dosage formscitations
- 2013A step toward development of printable dosage forms for poorly soluble drugscitations
Places of action
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article
A step toward development of printable dosage forms for poorly soluble drugs
Abstract
The purpose of this study was to formulate printable dosage forms for a poorly soluble drug (piroxicam; PRX) and to gain understanding of critical parameters to be considered during development of such dosage forms. Liquid formulations of PRX were printed on edible paper using piezoelectric inkjet printing (PIJ) and impression printing (flexography). The printed dosage forms were characterized using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and the amount of drug was determined using high-performance liquid chromatography. Solutions of PRX in polyethylene glycol 400 (PEG-400):ethanol (40:60) and in PEG-400 were found to be optimal formulations for PIJ and flexography, respectively. SEM-EDX analysis revealed no visible solid particles on the printed dosage forms indicating the drug most likely remained in solution after printing. More accurate drug deposition was obtained by PIJ as compared with flexography. More than 90% drug release was achieved within 5 min regardless of printing method used. The solubility of drug in solvents/cosolvents, rheological properties of formulations, properties of substrate, feasibility and accuracy of the printing methods, and detection limit of analytical techniques for characterization of printed dosage forms are some of the concerns that need to be addressed for development of printable dosage forms of poorly soluble drugs.