| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Blunn, Gw
University of Portsmouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2022Design and in vivo testing of novel single-stage tendon graft using polyurethane nanocomposite polymer for tendon reconstructioncitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implantscitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants.
- 2017Clinical cold welding of the modular total hip arthroplasty prosthesiscitations
- 2017Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineeringcitations
- 2017Fretting corrosion behavior of nitinol spinal rods in conjunction with titanium pedicle screwscitations
- 2016Corrosion at the head-neck interface of current designs of modular femoral componentscitations
- 2016Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentationcitations
- 2016Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffoldscitations
- 2015The effect of frictional torque and bending moment on corrosion at the taper interfacecitations
- 2015Lessons from retrievalscitations
- 2015Analysis of retrieved growth guidance sliding LSZ-4D devices for early onset scoliosis and investigation of the use of nitinol rods for this systemcitations
- 2015Silicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cellscitations
- 2014Low dose of propranolol does not affect rat osteotomy healing and callus strengthcitations
- 2013Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topographycitations
- 2011Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloycitations
- 2008Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.citations
- 2006Porous Ti-6Al-4V bone replacement materials produced by Selective Laser Sintering (SLS)
- 2004The effect of diamond like carbon and hydroxyapatite coatings on soft tissue reactions to external fixation screws under load
- 2000Fractographic examination of racing greyhound central (navicular) tarsal bone failure surfaces using scanning electron microscopy
Places of action
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article
Low dose of propranolol does not affect rat osteotomy healing and callus strength
Abstract
<p>Experimental studies suggest that the β-blocker propranolol stimulates bone formation but little work has investigated its effect on fracture healing. In this study, we examined if a low dose of propranolol, previously shown to be preventive against bone loss in rats, improves bone repair. Female Wistar rats were injected with saline or propranolol (0.1 mg/kg/day) (n = 20/group), 5 days a week for 8 weeks. Three weeks after the beginning of treatment, all rats underwent a mid-diaphyseal transverse osteotomy in the left femur. Radiographic analysis of ostetomy healing was performed 2 and 5 weeks after osteotomy. Rats were sacrificed at 5 weeks and femora collected for measurements of fracture strength by torsional testing, callus volume, and mineral content by micro-CT analysis and histology of fracture callus. Eighty nine percent of osteotomies achieved apparent radiological union by 5 weeks in both groups. Propranolol treatment did not significantly alter the torsional strength of the fractured femur compared with controls. The volume and mineralization of fracture callus at 5 weeks were not significantly different in both groups. Histology showed that endochondral ossification was not affected by propranolol. Altogether, our results demonstrate that propranolol using the regimen described does not significantly improve or inhibit rat osteotomy healing and mechanical strength.</p>