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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Ali, M. A. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ali, Wahaaj
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2024Cytocompatibility, cell‐material interaction, and osteogenic differentiation of MC3T3‐E1 pre‐osteoblasts in contact with engineered Mg/PLA compositescitations
- 2024Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applicationscitations
- 2024A phase-field model of mechanically-assisted corrosion of bioabsorbable metals
- 2023Bioabsorbable WE43 Mg alloy wires modified by continuous plasma-electrolytic oxidation for implant applications. Part I: Processing, microstructure and mechanical propertiescitations
- 2023Bioabsorbable WE43 Mg alloy wires modified by continuous plasma electrolytic oxidation for implant applications. Part II: Degradation and biological performancecitations
- 2023Effect of surface modification on interfacial behavior in bioabsorbable magnesium wire reinforced poly-lactic acid polymer compositescitations
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article
Cytocompatibility, cell‐material interaction, and osteogenic differentiation of MC3T3‐E1 pre‐osteoblasts in contact with engineered Mg/PLA composites
Abstract
<jats:title>Abstract</jats:title><jats:p>Bioabsorbable Mg wire‐reinforced poly‐lactic acid (PLA) matrix composites are potential candidate for load‐bearing orthopedic implants offering tailorable mechanical and degradation properties by stacking sequence, volume fraction and surface modification of Mg wires. In this study, we investigated the cytocompatibility, cell‐material interaction, and bone differentiation behavior of MC3T3‐E1 pre‐osteoblast cells for medical‐grade PLA, Mg/PLA, and PEO‐Mg/PLA (having PEO surface modification on Mg wires) composites. MTT and live/dead assay showed excellent biocompatibility of both composites while cell‐material interaction analysis revealed that cells were able to adhere and proliferate on the surface of composites. Cells on the longitudinal surface of composites showed a high and uniform cell density while those on transversal surfaces initially avoided Mg regions but later migrated back after the formation of the passivation layer. Bone differentiation tests showed that cells in extracts of PLA and composites were able to initiate the differentiation process as osteogenesis‐related gene expressions, alkaline phosphatase protein quantity, and calcium mineralization increased after 7 and 14 days of culture. Interestingly, the bone differentiation response of PEO‐Mg/PLA composite was found to be similar to medical‐grade PLA, proving its superiority over Mg/PLA composite.</jats:p>