| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kopp, Alexander
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Cytocompatibility, cell‐material interaction, and osteogenic differentiation of MC3T3‐E1 pre‐osteoblasts in contact with engineered Mg/PLA compositescitations
- 2024Combined severe plastic deformation processing of commercial purity titanium enables superior fatigue resistance for next generation implantscitations
- 2024Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applicationscitations
- 2023Bioabsorbable WE43 Mg alloy wires modified by continuous plasma-electrolytic oxidation for implant applications. Part I: Processing, microstructure and mechanical propertiescitations
- 2023Bioabsorbable WE43 Mg alloy wires modified by continuous plasma electrolytic oxidation for implant applications. Part II: Degradation and biological performancecitations
- 2023Effect of surface modification on interfacial behavior in bioabsorbable magnesium wire reinforced poly-lactic acid polymer compositescitations
- 2023Predicting localised corrosion and mechanical performance of a PEO surface modified rare earth magnesium alloy for implant use through in-silico modellingcitations
- 2023Linking the effect of localised pitting corrosion with mechanical integrity of a rare earth magnesium alloy for implant usecitations
- 2023An enhanced phenomenological model to predict surface-based localised corrosion of magnesium alloys for medical usecitations
- 2022Silk Fibroin as Adjuvant in the Fabrication of Mechanically Stable Fibrin Biocomposites.citations
- 2022An additively manufactured magnesium-aluminium alloy withstands seawater corrosioncitations
- 2021Influence of surface condition on the degradation behaviour and biocompatibility of additively manufactured WE43citations
- 2021Automated ex-situ detection of pitting corrosion and its effect on the mechanical integrity of rare earth magnesium alloy - WE43citations
- 2018Hemocompatibility of plasma electrolytic oxidation (PEO) coated Mg-RE and Mg-Zn-Ca alloys for vascular scaffold applicationscitations
- 2018Plasma Electrolytic Oxidation of Titanium Implant Surfaces: Microgroove-Structures Improve Cellular Adhesion and Viability
Places of action
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article
Cytocompatibility, cell‐material interaction, and osteogenic differentiation of MC3T3‐E1 pre‐osteoblasts in contact with engineered Mg/PLA composites
Abstract
<jats:title>Abstract</jats:title><jats:p>Bioabsorbable Mg wire‐reinforced poly‐lactic acid (PLA) matrix composites are potential candidate for load‐bearing orthopedic implants offering tailorable mechanical and degradation properties by stacking sequence, volume fraction and surface modification of Mg wires. In this study, we investigated the cytocompatibility, cell‐material interaction, and bone differentiation behavior of MC3T3‐E1 pre‐osteoblast cells for medical‐grade PLA, Mg/PLA, and PEO‐Mg/PLA (having PEO surface modification on Mg wires) composites. MTT and live/dead assay showed excellent biocompatibility of both composites while cell‐material interaction analysis revealed that cells were able to adhere and proliferate on the surface of composites. Cells on the longitudinal surface of composites showed a high and uniform cell density while those on transversal surfaces initially avoided Mg regions but later migrated back after the formation of the passivation layer. Bone differentiation tests showed that cells in extracts of PLA and composites were able to initiate the differentiation process as osteogenesis‐related gene expressions, alkaline phosphatase protein quantity, and calcium mineralization increased after 7 and 14 days of culture. Interestingly, the bone differentiation response of PEO‐Mg/PLA composite was found to be similar to medical‐grade PLA, proving its superiority over Mg/PLA composite.</jats:p>