| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Day, Richard
University College London
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024A review of impact drop testing of composite laminate plates
- 2024Influence of stacking sequence on flexural properties of hybrid carbon fibre reinforced polymer laminates
- 2024Lithium-loaded GelMA-Phosphate glass fibre constructs: Implications for astrocyte response.citations
- 2023A Test Rig for the Calibration of Strain Sensing Carbon Fibre
- 2022New generation of embedded planar optics for in-situ, through-thickness and real-time strain measurements in carbon fiber reinforced polymer composites during the cure processcitations
- 2021The effects of absorbing materials on the homogeneity of composite heating by microwave radiation
- 2017Aerospace composite cured by quickstep and autoclave processing techniques: Evaluation and comparison of reaction progress
- 2017Internal Model Control of a Domestic Microwave for Carbon Composite Curing
- 2008Comparison of the mechanical and physical properties of a carbon fibre epoxy composite manufactured by resin transfer moulding using conventional and microwave heating
- 2002Flexural and interlaminar shear strength properties of carbon fibre/epoxy composites cured thermally and with microwave radiation
Places of action
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article
Lithium-loaded GelMA-Phosphate glass fibre constructs: Implications for astrocyte response.
Abstract
Combinations of different biomaterials with their own advantages as well as functionalization with other components have long been implemented in tissue engineering to improve the performance of the overall material. Biomaterials, particularly hydrogel platforms, have shown great potential for delivering compounds such as drugs, growth factors, and neurotrophic factors, as well as cells, in neural tissue engineering applications. In central the nervous system, astrocyte reactivity and glial scar formation are significant and complex challenges to tackle for neural and functional recovery. GelMA hydrogel-based tissue constructs have been developed in this study and combined with two different formulations of phosphate glass fibers (PGFs) (with Fe<sup>3+</sup> or Ti<sup>2+</sup> oxide) to impose physical and mechanical cues for modulating astrocyte cell behavior. This study was also aimed at investigating the effects of lithium-loaded GelMA-PGFs hydrogels in alleviating astrocyte reactivity and glial scar formation offering novel perspectives for neural tissue engineering applications. The rationale behind introducing lithium is driven by its long-proven therapeutic benefits in mental disorders, and neuroprotective and pronounced anti-inflammatory properties. The optimal concentrations of lithium and LPS were determined in vitro on primary rat astrocytes. Furthermore, qPCR was conducted for gene expression analysis of GFAP and IL-6 markers on primary astrocytes cultured 3D into GelMA and GelMA-PGFs hydrogels with and without lithium and in vitro stimulated with LPS for astrocyte reactivity. The results suggest that the combination of bioactive phosphate-based glass fibers and lithium loading into GelMA structures may impact GFAP expression and early IL-6 expression. Furthermore, GelMA-PGFs (Fe) constructs have shown improved performance in modulating glial scarring over GFAP regulation.