| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Martin, Richard A.
Aston University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (40/40 displayed)
- 2024Multifunctional gallium doped bioactive glasses: a targeted delivery for antineoplastic agents and tissue repair against osteosarcomacitations
- 2020Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo models
- 2020Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo modelscitations
- 2020Photo-polymerisation variables influence the structure and subsequent thermal response of dental resin matricescitations
- 2019The antimicrobial efficacy of hypoxia mimicking cobalt oxide doped phosphate-based glasses against clinically relevant Gram positive, Gram negative bacteria and a fungal straincitations
- 2019The antimicrobial efficacy of hypoxia mimicking cobalt oxide doped phosphate-based glasses against clinically relevant Gram positive, Gram negative bacteria and a fungal strain
- 2019The Antimicrobial Efficacy of Hypoxia Mimicking Cobalt Oxide Doped Phosphate-Based Glasses against Clinically Relevant Gram Positive, Gram Negative Bacteria and a Fungal Straincitations
- 2018Comprehensive in vitro and in vivo studies of novel melt-derived Nb-substituted 45S5 bioglass reveal its enhanced bioactive properties for bone healingcitations
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29Si solid-state NMR
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29Si solid-state NMRcitations
- 2017Atomic structure of chlorine containing calcium silicate glasses by neutron diffraction and 29 Si solid-state NMRcitations
- 2017Atomic structure of Mg-based metallic glasses from molecular dynamics and neutron diffraction
- 2017Atomic structure of Mg-based metallic glasses from molecular dynamics and neutron diffractioncitations
- 2016Controlling particle size in the Stöber process and incorporation of calciumcitations
- 2016Bioactive sol-gel glasses at the atomic scale:the complementary use of advanced probe and computer modeling methods
- 2016Bioactive sol-gel glasses at the atomic scale : the complementary use of advanced probe and computer modeling methods
- 2016Probing crystallisation of a fluoro-apatite - mullite system using neutron diffractioncitations
- 2016Bioactive sol-gel glasses at the atomic scalecitations
- 2015Novel sol–gel preparation of (P2O5)0.4–(CaO)0.25–(Na2O)X–(TiO2)(0.35−X) bioresorbable glasses (X = 0.05, 0.1, and 0.15)citations
- 2014The effect of bioglass addition on mechanical and physical properties of photoactive UDMA-TEGDMA resin compositescitations
- 2013Effects of rare-earth co-doping on the local structure of rare-earth phosphate glasses using high and low energy X-ray diffractioncitations
- 2012Characterizing the hierarchical structures of bioactive sol-gel silicate glass and hybrid scaffolds for bone regenerationcitations
- 2012Effect of calcium source on structure and properties of sol-gel derived bioactive glassescitations
- 2012Structural characterization of titanium-doped Bioglass using isotopic substitution neutron diffractioncitations
- 2012Titanium phosphate glass microspheres for bone tissue engineering.citations
- 2011An X-ray micro-fluorescence study to investigate the distribution of Al, Si, P and Ca ions in the surrounding soft tissue after implantation of a calcium phosphate-mullite ceramic composite in a rabbit animal modelcitations
- 2010Structure of liquid and glassy ZnCl2citations
- 2009A study of the formation of amorphous calcium phosphate and hydroxyapatite on melt quenched Bioglass(A (R)) using surface sensitive shallow angle X-ray diffractioncitations
- 2009A molecular dynamics model of the atomic structure of dysprosium alumino-phosphate glasscitations
- 2009Bioactive glass sol-gel foam scaffoldscitations
- 2008Structure and thermal properties of yttrium alumino-phosphate glassescitations
- 2007The structure of the rare-earth phosphate glass (Sm2O3)0.205(P2O5)0.795 studied by anomalous dispersion neutron diffractioncitations
- 2006Direct observation of R...R distances in rare-earth (R) phosphate glasses by magnetic difference neutron diffractioncitations
- 2006Silica-clad neodymium-doped lanthanum phosphate fibers and fiber laserscitations
- 2006Direct observation of R.R distances in rare-earth (R) phosphate glasses by magnetic difference neutron diffractioncitations
- 2004Structure of rare-earth phosphate glasses by neutron diffractioncitations
- 2004Magnetic Differences on GEM - direct observation of closest R.R approach in rare-earth phosphate glasses
- 2003Identification of the relative distribution of rare-earth ions in phosphate glassescitations
- 2003Structure of lanthanum and cerium phosphate glasses by the method of isomorphic substitution in neutron diffractioncitations
- 2003Structure of dysprosium and holmium phosphate glasses by the method of isomorphic substitution in neutron diffractioncitations
Places of action
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article
Evaluation of effectiveness of 45S5 bioglass doped with niobium for repairing critical-sized bone defect in in vitro and in vivo models
Abstract
<p>Here, we investigated the biocompatibility of a bioactive sodium calcium silicate glass containing 2.6 mol% Nb<sub>2</sub>O<sub>5</sub> (denoted BGPN2.6) and compare the results with the archetypal 45S5 bioglass. The glass bioactivity was tested using a range of in vitro and in vivo experiments to assess its suitability for bone regeneration applications. in vitro studies consisted of assessing the cytocompatibility of the BGPN2.6 glass with bone-marrow-derived mesenchymal stem cells (BM-MSCs). Systemic biocompatibility was verified by means of the quantification of biochemical markers and histopathology of liver, kidneys, and muscles. The glass genotoxicity was assessed using the micronucleus test. The regeneration of a calvarial defect was assessed using both qualitative and quantitative analysis of three-dimensional microcomputed tomography images. The BGPN2.6 glass was not cytotoxic to BM-MSCs. It is systemically biocompatible causing no signs of damage to high metabolic and excretory organs such as the liver and kidneys. No mutagenic potential was observed in the micronucleus test. MicroCT images showed that BGPN2.6 was able to nearly fully regenerate a critical-sized calvarial defect and was far superior to standard 45S5 Bioglass. Defects filled with BGPN2.6 glass showed over 90% coverage compare to just 66% for 45S5 Bioglass. For one animal the defect was completely filled in 8 weeks. These results clearly show that Nb-containing bioactive glasses are a safe and effective biomaterial for bone replacement.</p>