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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Reifenrath, Janin
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2020Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedicscitations
- 2018In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties.citations
- 2016Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval-related considerations.citations
- 2015MgNd2 alloy in contact with nasal mucosa: an in vivo and in vitro approach.citations
- 2015A Novel Shape Memory Plate Osteosynthesis for Noninvasive Modulation of Fixation Stiffness in a Rabbit Tibia Osteotomy Modelcitations
- 2015In vivo evaluation of a magnesium-based degradable intramedullary nailing system in a sheep modelcitations
- 2015A novel biodegradable frontal sinus stent (MgNd2): a long-term animal study.citations
- 2015The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study
- 2014Comparative in vitro study and biomechanical testing of two different magnesium alloys.citations
- 2013Increased accumulation of magnetic nanoparticles by magnetizable implant materials for the treatment of implant-associated complications
- 2013Influence of stress on the degradation behavior of Mg LAE442 implant systems
- 2013Influence of the grain size on the in vivo degradation behaviour of the magnesium alloy LAE442citations
- 2012In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal model
- 2012In vivo assessment of the host reactions to the biodegradation of the two novel magnesium alloys ZEK100 and AX30 in an animal modelcitations
- 2011In vivo degradation behavior of the magnesium alloy land442 in rabbit tibiaecitations
Places of action
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article
Magnesium alloys: A stony pathway from intensive research to clinical reality. Different test methods and approval-related considerations.
Abstract
The first degradable implant made of a magnesium alloy, a compression screw, was launched to the clinical market in March 2013. Many different complex considerations are required for the marketing authorization of degradable implant materials. This review gives an overview of existing and proposed standards for implant testing for marketing approval. Furthermore, different common in vitro and in vivo testing methods are discussed. In some cases, animal tests are inevitable to investigate the biological safety of a novel medical material. The choice of an appropriate animal model is as important as subsequent histological examination. Furthermore, this review focuses on the results of various mechanical tests to investigate the stability of implants for temporary use. All the above aspects are examined in the context of development and testing of magnesium-based biomaterials and their progress them from bench to bedside. A brief history of the first market launch of a magnesium-based degradable implant is given. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 329-347, 2017.