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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Langer, Robert
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Publications (9/9 displayed)
- 2024Monomer centred selectivity guidelines for sulfurated ring-opening copolymerisations
- 2024Monomer centred selectivity guidelines in sulfurated ring-opening copolymerisations
- 2022Unique design approach to realize an O-band laser monolithically integrated on 300 mm Si substrate by nano-ridge engineeringcitations
- 2014Ionizable Amphiphilic Dendrimer‐Based Nanomaterials with Alkyl‐Chain‐Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivocitations
- 2009Partial least squares regression as a powerful tool for investigating large combinatorial polymer librariescitations
- 2009<i>In vitro</i> and <i>in vivo</i> degradation of poly(1,3‐diamino‐2‐hydroxypropane‐<i>co</i>‐polyol sebacate) elastomerscitations
- 2008Microfluidic platform for controlled synthesis of polymeric nanoparticlescitations
- 2008TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettabilitycitations
- 2007Why inhaling salt water changes what we exhalecitations
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article
<i>In vitro</i> and <i>in vivo</i> degradation of poly(1,3‐diamino‐2‐hydroxypropane‐<i>co</i>‐polyol sebacate) elastomers
Abstract
<jats:title>Abstract</jats:title><jats:p>Biomaterials with a wide range of tunable properties are desirable for application‐specific purposes. We have previously developed a class of elastomeric poly(ester amides) based on the amine alcohol 1,3‐diamino‐2‐hydroxypropane termed poly(1,3‐diamino‐2‐hydroxypropane‐<jats:italic>co</jats:italic>‐polyol sebacate) or APS. In this work, we have synthesized and characterized formulations of APS polymers and studied the degradation of these polymers <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic>. It was found that the chemical, physical, and mechanical properties of APS polymers could be tuned by adjusting monomer feed ratios and polymerization conditions. The degradation kinetics could also be greatly influenced by altering the formulation of APS polymers. <jats:italic>In vivo</jats:italic> degradation half‐lives ranged from 6 to ∼100 weeks. Furthermore, the dominant degradation mechanism (i.e. hydrolytic or enzymatic) could be controlled by adjusting the specific formulation of the APS polymer. On the basis of the observed <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> biodegradation phenomena, we also propose that the primary modes of degradation are composition dependent. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009</jats:p>