Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (82/82 displayed)

  • 2011Nanostructured polymer blends: from core/shell nanoobjects to continuous three-phase morphologiescitations
  • 2011Anionically prepared poly(epsilon-caprolactam-co-epsilon-caprolactone) and poly(epsilon-caprolactam-co-delta-valerolactone) copolymers: thermal and mechanical properties17citations
  • 2011Synthesis and thermal properties of linear amphiphilic diblock copolymers of L-lactide and 2-dimethylaminoethyl methacrylate37citations
  • 2011Hydrogel nanocomposites: a potential UV/blue light filtering material for ophthalmic lenses4citations
  • 2010Polymers in modern ophthalmic implants—Historical background and recent advances78citations
  • 2009Stainless steel grafting of hyperbranched polymer brushes with an antibacterial activity: synthesis, characterization and properties58citations
  • 2008Synthesis of novel well-defined poly(vinyl acetate)-b-poly(acrylomtrile) and derivatized water-soluble poly(vinyl alcohol)-b-poly(acrylic acid) block copolymers by cobalt-mediated radical polymerizationcitations
  • 2008Synthesis of novel well-defined poly(vinyl acetate)-b-poly(acrylonitrile) and derivatized water-soluble poly(vinyl alcohol)-b-poly(acrylic acid) block copolymers by cobalt-mediated radical polymerization91citations
  • 2008Atom transfer radical polymerization of MMA with a macromolecular ligand in a fluorinated solvent and in supercritical carbon dioxide35citations
  • 2008Foams of polycaprolactone/MWNT nanocomposites for efficient EMI reduction296citations
  • 2008Coating of gold nanoparticles by thermosensitive poly(N-isopropylacrylamide) end-capped by biotin86citations
  • 2008Macromolecular engineering of aliphatic polyesters by ring-opening polymerizationcitations
  • 2007Multiwalled carbon nanotube/poly(epsilon-caprolactone) nanocomposites with exceptional electromagnetic interference shielding properties145citations
  • 2007Controlled synthesis of carboxylic acid end-capped poly(heptadecafluorodecyl acrylate) and copolymers with 2-hydroxyethyl acrylate28citations
  • 2007Controlled RAFT synthesis of polyacrylonitrile-b-poly(acrylic acid) diblocks as precursors of carbon nanocapsules with assistance of gold nanoparticles42citations
  • 2007Structure and properties of a semifluorinated diblock copolymer modified epoxy blend87citations
  • 2007Copolymerization of vinyl acetate with 1-octene and ethylene by cobalt-mediated radical polymerization47citations
  • 2006Carbon nanotube composites for broadband microwave absorbing materials8citations
  • 2006First insights into electrografted polymers by AFM-based force spectroscopy37citations
  • 2006Poly(D,L-lactide) (PDLLA) foams with TiO2 nanoparticles and PDLLA/TiO2-Bioglass (R) foam composites for tissue engineering scaffolds60citations
  • 2006Electrografting of thin polymer films: Three strategies for the tailoring of functional adherent coatings9citations
  • 2006Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings22citations
  • 2006pH-Responsive diblock copolymers prepared by the dual initiator strategy47citations
  • 2006New nanostructured materials based on fullerene and biodegradable polyesters38citations
  • 2006Synthesis of amphiphilic copolymers of poly(ethylene oxide) and poly(epsilon-caprolactone) with different architectures, and their role in the preparation of stealthy nanoparticles59citations
  • 2005Quinone transfer radical polymerization (QTRP) of styrene: Catalysis by different metal complexes27citations
  • 2005Adsorption of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers at the silica-water interfacecitations
  • 2005Wetting of bioactive glass surfaces by poly(α-hydroxyacid) melts: Interaction between Bioglass® and biodegradable polymers27citations
  • 2005In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass100citations
  • 2005Quinone transfer radical polymerization of styrene catalyzed by metal complexes in the presence of various o-quinones18citations
  • 2005Synthesis of poly(vinyl acetate) and poly(vinyl alcohol) containing block copolymers by combination of cobalt-mediated radical polymerization and ATRP101citations
  • 2005Synthesis of end-functional poly(vinyl acetate) by cobalt-mediated radical polymerization118citations
  • 2005Mechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds for bone tissue engineering205citations
  • 2005Tailoring of thin polymer films chemisorbed onto conductive surfaces by electrograftingcitations
  • 2005Study of the connectivity properties of Bioglass®-filled polylactide foam scaffolds by image analysis and impedance spectroscopy13citations
  • 2004Functionalization of multi-walled carbon nanotubes by electrografting of polyacrylonitrile51citations
  • 2004Solid-state NMR study of intercalated species in poly(epsilon-caprolactone)/clay nanocomposites40citations
  • 2004Texture characterisation of foams based on poly(e-caprolactone) - clay nanocomposites by image analysis of X-ray microtomography and mercury porosimetrycitations
  • 2004Nafion-layered silicate nanocomposite membrane for fuel cell application16citations
  • 2004Electrodeposition of mixed adherent thin films of poly(ethyl acrylate) and polyacrylonitrile onto nickel2citations
  • 2004Nanostructured polyamide by reactive blending. 1. Effect of the reactive diblock composition23citations
  • 2004Porous poly(α-hydroxyacid)/Bioglass® composite scaffolds for bone tissue engineering. I: preparation and in vitro characterisation311citations
  • 2004Recent developments in the ring-opening polymerization of epsilon-caprolactone and derivatives initiated by tin(IV) alkoxides28citations
  • 2003Preparation, characterization, and in vitro degradation of bioresorbable and bioactive composites based on Bioglass (R)-filled polylactide foams168citations
  • 2003Polymer/layered silicate nanocomposites by combined intercalative polymerization and melt intercalation: a masterbatch process156citations
  • 2003In situ formation of yttrium alkoxides: A versatile and efficient catalyst for the ROP of epsilon-caprolactonecitations
  • 2003Immobilization of silver in polypyrrole/polyanion composite coatings: Preparation, characterization, and antibacterial activity82citations
  • 20032-oxepane-1,5-dione: a precursor of a novel class of versatile semicrystalline biodegradable (co)-polyesterscitations
  • 2003Bioresorbable and bioactive composite materials based on polylactide foams filled with and coated by Bioglass (R) particles for tissue engineering applications107citations
  • 2003Polymerization-filled composites and nanocomposites by coordination catalysis35citations
  • 2003Synthesis and characterization of random copolyesters of epsilon-caprolactone and 2-oxepane-1,5-dione59citations
  • 2003Exfoliated polylactide/clay nanocomposites by in-situ coordination-insertion polymerization138citations
  • 2002Polyethylene-layered silicate nanocomposites prepared by the polymerization-filling technique: synthesis and mechanical properties246citations
  • 2002Immobilization of actinide ions in thin layers of polypyrrole/polyacrylamidoglycolic acid (PPy/PAGA) composite. Application to the preparation of alpha spectrometry sources6citations
  • 2002Poly(epsilon-caprolactone)/clay nanocomposites prepared by melt intercalation: mechanical, thermal and rheological properties394citations
  • 2002Controlled synthesis of anthracene-labeled omega-amine polystyrene to be used as a probe for interfacial reaction with mutually reactive PMMAcitations
  • 2002Development and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications336citations
  • 2002Layered silicate/polyester nanohybrids by controlled ring-opening polymerizationcitations
  • 2002Full electrochemical synthesis of conducting polymer films chemically grafted to conducting surfaces43citations
  • 2002Anionic polymerisation of methyl methacrylate with complex initiator system2citations
  • 2002Living cationic polymerization of delta-valerolactone and synthesis of high molecular weight homopolymer and asymmetric telechelic and block copolymer110citations
  • 2002Polyester layered silicate nanohybrids by controlled grafting polymerization82citations
  • 2001Poly(ϵ-caprolactone) layered silicate nanocomposites27citations
  • 2001Poly(e-caprolactone) layered silicate nanocomposites: effect of clay surface modifiers on the melt intercalation processcitations
  • 2001Probing thermoplastic matrix-carbon fiber interphases. 1. Preferential segregation of low molar mass chains to the interface15citations
  • 2001Full-electrochemical preparation of conducting/insulating binary polymer films25citations
  • 2001Ionic end-capping of (semi)telechelic polymers by mesogens: a novel route to liquid crystalline polymers13citations
  • 2001Metallocene catalyzed polymerization of ethylene in the presence of graphite. 2. Structure and electrical properties of the composites27citations
  • 2001Electrochemical strategies for the strengthening of polymer – metal interfacescitations
  • 2001Reactive blending of functional PS and PMMA: interfacial behavior of in situ formed graft copolymerscitations
  • 2000New developments on the ring opening polymerisation of polylactide96citations
  • 2000Novel functionalization routes of poly(ε-caprolactone)citations
  • 2000Ring-Opening Polymerization of γ-bromo-ε-caprolactone : A novel route to functionalized aliphatic polyesters87citations
  • 2000Ring-opening polymerization of 6-hydroxynon-8-enoic acid lactone : Novel biodegradable copolymers containing allyl pendent groupscitations
  • 2000Microphase separation at the surface of block copolymers, as studied with atomic force microscopy31citations
  • 2000Synthesis, morphology, and mechanical properties of poly(methyl methacrylate)-b-poly(n-butyl acrylate)-b-poly (methyl methacrylate) triblocks. Ligated anionic polymerization vs atom transfer radical polymerization93citations
  • 2000Reactive compatibilization of PC/PVDF polymer blends by zinc carboxylate containing poly(methylmethacrylate)ionomers15citations
  • 2000Ternary polymer blend with core-shell dispersed phases: effect of the core-forming polymer on phase morphology and mechanical properties78citations
  • 2000The use of conducting polymers as cathodes for the electrochemical deposition of magnetic transition metal/rare alloys8citations
  • 2000First example of an unsymmetrical difunctional monomer polymerizable by two living/controlled methodscitations
  • 2000Reactive compatibilization of SAN/EPR blends: Effect of kinetics of the compatibilization reaction on the interfacial adhesioncitations
  • 2000Reactive compatibilization of SAN/EPR blends: Effect of rubber content and reactivity of the SAN functional groupscitations

Places of action

Chart of shared publication
Leclère, Philippe
3 / 28 shared
Lazzaroni, Roberto
6 / 59 shared
Detrembleur, Christophe
16 / 108 shared
Lei, Liangcai
1 / 1 shared
Jeusette, Mélanie
1 / 4 shared
Toncheva, Natalia
1 / 1 shared
Mateva, Rosa
1 / 1 shared
Prudhomme, Robert E.
1 / 1 shared
Bazuin, C. Géraldine
1 / 1 shared
Kryuchkov, Maksym A.
1 / 1 shared
Vertruyen, Bénédicte
1 / 55 shared
De Pauw-Gillet, Marie-Claire
1 / 4 shared
Pagnoulle, Christophe
13 / 14 shared
Jérôme, Christine
22 / 126 shared
Bozukova, Dimitriya
2 / 3 shared
Gilbert, Bernard
2 / 8 shared
Gabriel, Sabine
3 / 3 shared
Voccia, Samuel
3 / 3 shared
Ignatova, Milena
2 / 2 shared
Cossement, Damien
1 / 27 shared
Detrembleur, C.
1 / 1 shared
Voets, Ik Ilja
1 / 5 shared
Warnant, Jérôme
2 / 2 shared
Debuigne, Antoine
6 / 23 shared
Keizer, Arie De
1 / 4 shared
Cohen Stuart, Martien A.
2 / 6 shared
De Keizer, Arie
1 / 2 shared
Voets, Ilja
1 / 9 shared
Calberg, Cédric
14 / 29 shared
Grignard, Bruno
3 / 32 shared
Bednarz, Lukasz
3 / 3 shared
Huynen, Isabelle
3 / 30 shared
Thomassin, Jean-Michel
4 / 45 shared
Greisch, Jean-François
1 / 1 shared
Aqil, Abdelhafid
3 / 22 shared
Qiu, Hongjin
1 / 2 shared
De Pauw, Edwin
1 / 5 shared
Lecomte, Philippe
7 / 17 shared
Lou, Xudong
5 / 5 shared
Saib, Aimad
2 / 4 shared
Ocando, Connie
1 / 7 shared
Pena, Cristina
1 / 1 shared
Mondragon, Inaki
1 / 2 shared
Tercjak, Agnieszka
1 / 11 shared
Mecerreyes, David
4 / 24 shared
Kortaberria, Galder
1 / 13 shared
Serrano, Elena
1 / 6 shared
Carrasco, Pedro M.
1 / 3 shared
Bryaskova, Rayna
1 / 2 shared
Degée, Philippe
5 / 39 shared
Willet, Nicolas
4 / 4 shared
Dubois, Philippe
4 / 24 shared
Bailly, Christian
1 / 58 shared
Daussin, Raphaël
1 / 1 shared
Cuenot, Stéphane
1 / 12 shared
Duwez, Anne-Sophie
1 / 8 shared
Fustin, Charles-André
1 / 7 shared
Jonas, Am
1 / 13 shared
Chung, Wendy
1 / 2 shared
Boccaccini, Aldo R.
9 / 77 shared
Blaker, Jonny J.
3 / 15 shared
Maquet, Véronique
10 / 11 shared
Nazhat, Showan N.
1 / 6 shared
Serwas, Harry
1 / 1 shared
Labaye, David-Emmanuel
2 / 2 shared
Bertrand, Olivier F.
1 / 1 shared
Gautier, Sandrine
2 / 2 shared
Du Prez, Filip E.
1 / 11 shared
Van Camp, Wim
1 / 3 shared
Bernaerts, Katrien V.
1 / 1 shared
Manolova, Nevena
1 / 2 shared
Rashkov, Iliya
1 / 2 shared
Mouithys-Mickalad, Ange
1 / 1 shared
Stoilova, Olya
1 / 2 shared
Van Butsele, Kathy
1 / 1 shared
Rieger, Jutta
1 / 5 shared
Passirani, Catherine
1 / 2 shared
Benoît, Jean-Pierre
1 / 1 shared
Caille, Jean-Raphaël
4 / 4 shared
Rojas, O. J.
1 / 3 shared
Vangeyte, Patrick
1 / 1 shared
Claesson, P. M.
1 / 5 shared
Auvray, Loïc
1 / 1 shared
Heinrich, M.
1 / 20 shared
Leyh, Bernard
1 / 2 shared
Bismarck, Alexander
1 / 142 shared
Day, Richard M.
1 / 4 shared
Forbes, Alastair
1 / 3 shared
Nazhat, S. N.
1 / 5 shared
Pirard, Jean-Paul
2 / 15 shared
Blacher, Silvia
3 / 8 shared
Petrov, Petar
1 / 3 shared
Hrobarikova, J.
1 / 2 shared
Robert, J. L.
1 / 2 shared
Grandjean, Jean
1 / 1 shared
Léonard, Angélique
1 / 19 shared
Crine, Michel
1 / 6 shared
Stassin, F.
1 / 2 shared
Pirard, René
1 / 7 shared
Bizzari, Didier
1 / 1 shared
Germain, Albert
1 / 5 shared
Caldarella, Giuseppe
1 / 2 shared
Baute, Noëlle
2 / 2 shared
Poleunis, Claude
1 / 30 shared
Legras, Roger
2 / 13 shared
Brédas, Jean-Luc
5 / 6 shared
Bertrand, Patrick
1 / 27 shared
Geskin, Victor M.
1 / 1 shared
Jonas, Alain M.
2 / 18 shared
Arys, Xavier
1 / 1 shared
Koulic, Christian
3 / 3 shared
Nothinger, I.
2 / 2 shared
Pravata, Laurent
2 / 2 shared
Stassin, Fabrice
1 / 2 shared
Pantoustier, Nadège
6 / 11 shared
Alexandre, Michaël
10 / 49 shared
Henrist, Catherine
3 / 32 shared
Rulmont, André
3 / 14 shared
Lepoittevin, Bénédicte
4 / 10 shared
Devalckenaere, Myriam
2 / 3 shared
Dubois, Philippe
11 / 234 shared
Martin, Eric
1 / 16 shared
Strivay, David
1 / 4 shared
Lenoir, Sandrine
1 / 1 shared
Labaye, David
1 / 1 shared
Latere Dwanisa, Jean-Pierre
2 / 2 shared
Notingher, I.
1 / 1 shared
Paul, Marie Amélie
1 / 2 shared
Garces, Juan M.
1 / 1 shared
Sun, Tao
1 / 7 shared
Mignosin, P.
1 / 1 shared
Leroy, D.
1 / 3 shared
Martinot, Lucien
5 / 6 shared
Lambert, B.
1 / 3 shared
Kubies, Dana
1 / 2 shared
Yin, Zhihui
2 / 2 shared
Roether, J. A.
1 / 24 shared
Hench, L. L.
1 / 4 shared
Gueskin, V. M.
1 / 1 shared
Louette, P.
1 / 3 shared
Lazzaroni, R.
1 / 10 shared
Nugay, Nihan
1 / 1 shared
Nugay, Turgut
1 / 1 shared
Cloots, Rudi
2 / 55 shared
Carlier, V.
1 / 1 shared
Sclavons, M.
1 / 2 shared
Thibaut, Anne
1 / 3 shared
Rodrigue, Dominique
1 / 1 shared
Riga, J.
1 / 2 shared
Mertens, Marc
2 / 2 shared
Geskin, V.
1 / 2 shared
Bodart, Isabelle
1 / 1 shared
Gohy, Jean-François
1 / 6 shared
Pluta, Miroslaw
1 / 3 shared
Geskin, Viktor M.
1 / 1 shared
Jacobsen, Sven
1 / 1 shared
Fritz, Hans-Gerhard
1 / 1 shared
Halleux, Olivier
2 / 2 shared
Mazza, Michaël
2 / 2 shared
Hedrick, James L.
3 / 4 shared
Miller, Robert D.
2 / 2 shared
Tong, Jiang Dong
1 / 1 shared
Rasmont, A.
1 / 1 shared
Doneux, C.
1 / 1 shared
Lambin, G.
1 / 1 shared
Moineau, Georges
1 / 1 shared
Tong, Jiang-Dong
1 / 1 shared
Moussaif, Noureddine
1 / 1 shared
Luzinov, Igor
1 / 1 shared
Leroy, Delphine
1 / 2 shared
Zhan, H.
1 / 3 shared
Licour, C.
1 / 1 shared
Chapelle, Gérard
1 / 1 shared
Humes, J.
1 / 1 shared
San Roman, J.
1 / 14 shared
Martin, Philippe
1 / 5 shared
Chart of publication period
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Co-Authors (by relevance)

  • Leclère, Philippe
  • Lazzaroni, Roberto
  • Detrembleur, Christophe
  • Lei, Liangcai
  • Jeusette, Mélanie
  • Toncheva, Natalia
  • Mateva, Rosa
  • Prudhomme, Robert E.
  • Bazuin, C. Géraldine
  • Kryuchkov, Maksym A.
  • Vertruyen, Bénédicte
  • De Pauw-Gillet, Marie-Claire
  • Pagnoulle, Christophe
  • Jérôme, Christine
  • Bozukova, Dimitriya
  • Gilbert, Bernard
  • Gabriel, Sabine
  • Voccia, Samuel
  • Ignatova, Milena
  • Cossement, Damien
  • Detrembleur, C.
  • Voets, Ik Ilja
  • Warnant, Jérôme
  • Debuigne, Antoine
  • Keizer, Arie De
  • Cohen Stuart, Martien A.
  • De Keizer, Arie
  • Voets, Ilja
  • Calberg, Cédric
  • Grignard, Bruno
  • Bednarz, Lukasz
  • Huynen, Isabelle
  • Thomassin, Jean-Michel
  • Greisch, Jean-François
  • Aqil, Abdelhafid
  • Qiu, Hongjin
  • De Pauw, Edwin
  • Lecomte, Philippe
  • Lou, Xudong
  • Saib, Aimad
  • Ocando, Connie
  • Pena, Cristina
  • Mondragon, Inaki
  • Tercjak, Agnieszka
  • Mecerreyes, David
  • Kortaberria, Galder
  • Serrano, Elena
  • Carrasco, Pedro M.
  • Bryaskova, Rayna
  • Degée, Philippe
  • Willet, Nicolas
  • Dubois, Philippe
  • Bailly, Christian
  • Daussin, Raphaël
  • Cuenot, Stéphane
  • Duwez, Anne-Sophie
  • Fustin, Charles-André
  • Jonas, Am
  • Chung, Wendy
  • Boccaccini, Aldo R.
  • Blaker, Jonny J.
  • Maquet, Véronique
  • Nazhat, Showan N.
  • Serwas, Harry
  • Labaye, David-Emmanuel
  • Bertrand, Olivier F.
  • Gautier, Sandrine
  • Du Prez, Filip E.
  • Van Camp, Wim
  • Bernaerts, Katrien V.
  • Manolova, Nevena
  • Rashkov, Iliya
  • Mouithys-Mickalad, Ange
  • Stoilova, Olya
  • Van Butsele, Kathy
  • Rieger, Jutta
  • Passirani, Catherine
  • Benoît, Jean-Pierre
  • Caille, Jean-Raphaël
  • Rojas, O. J.
  • Vangeyte, Patrick
  • Claesson, P. M.
  • Auvray, Loïc
  • Heinrich, M.
  • Leyh, Bernard
  • Bismarck, Alexander
  • Day, Richard M.
  • Forbes, Alastair
  • Nazhat, S. N.
  • Pirard, Jean-Paul
  • Blacher, Silvia
  • Petrov, Petar
  • Hrobarikova, J.
  • Robert, J. L.
  • Grandjean, Jean
  • Léonard, Angélique
  • Crine, Michel
  • Stassin, F.
  • Pirard, René
  • Bizzari, Didier
  • Germain, Albert
  • Caldarella, Giuseppe
  • Baute, Noëlle
  • Poleunis, Claude
  • Legras, Roger
  • Brédas, Jean-Luc
  • Bertrand, Patrick
  • Geskin, Victor M.
  • Jonas, Alain M.
  • Arys, Xavier
  • Koulic, Christian
  • Nothinger, I.
  • Pravata, Laurent
  • Stassin, Fabrice
  • Pantoustier, Nadège
  • Alexandre, Michaël
  • Henrist, Catherine
  • Rulmont, André
  • Lepoittevin, Bénédicte
  • Devalckenaere, Myriam
  • Dubois, Philippe
  • Martin, Eric
  • Strivay, David
  • Lenoir, Sandrine
  • Labaye, David
  • Latere Dwanisa, Jean-Pierre
  • Notingher, I.
  • Paul, Marie Amélie
  • Garces, Juan M.
  • Sun, Tao
  • Mignosin, P.
  • Leroy, D.
  • Martinot, Lucien
  • Lambert, B.
  • Kubies, Dana
  • Yin, Zhihui
  • Roether, J. A.
  • Hench, L. L.
  • Gueskin, V. M.
  • Louette, P.
  • Lazzaroni, R.
  • Nugay, Nihan
  • Nugay, Turgut
  • Cloots, Rudi
  • Carlier, V.
  • Sclavons, M.
  • Thibaut, Anne
  • Rodrigue, Dominique
  • Riga, J.
  • Mertens, Marc
  • Geskin, V.
  • Bodart, Isabelle
  • Gohy, Jean-François
  • Pluta, Miroslaw
  • Geskin, Viktor M.
  • Jacobsen, Sven
  • Fritz, Hans-Gerhard
  • Halleux, Olivier
  • Mazza, Michaël
  • Hedrick, James L.
  • Miller, Robert D.
  • Tong, Jiang Dong
  • Rasmont, A.
  • Doneux, C.
  • Lambin, G.
  • Moineau, Georges
  • Tong, Jiang-Dong
  • Moussaif, Noureddine
  • Luzinov, Igor
  • Leroy, Delphine
  • Zhan, H.
  • Licour, C.
  • Chapelle, Gérard
  • Humes, J.
  • San Roman, J.
  • Martin, Philippe
OrganizationsLocationPeople

article

In vitro and in vivo analysis of macroporous biodegradable poly(D,L-lactide-co-glycolide) scaffolds containing bioactive glass

  • Day, Richard M.
  • Boccaccini, Aldo R.
  • Jérôme, Robert
  • Maquet, Véronique
  • Forbes, Alastair
Abstract

Recent studies have demonstrated the angiogenic potential of 45S5 Bioglass. However, it is not known whether the angiogenic properties of Bioglass remain when the bioactive glass particles are incorporated into polymer composites. The objectives of the current study were to investigate the angiogenic properties of 45S5 Bioglass particles incorporated into biodegradable polymer composites. In vitro studies demonstrated that fibroblasts cultured on discs consisting of specific quantities of Bioglass particles mixed into poly(D,L-lactide-co-glycolide) secreted significantly increased quantities of vascular endothelial growth factor. The optimal quantity of Bioglass particles determined from the in vitro experiments was incorporated into three-dimensional macroporous poly(D,L-lactide-co-glycolide) foam scaffolds. The foam scaffolds were fabricated using either compression molding or thermally induced phase separation processes. The foams were implanted subcutaneously into mice for periods of up to 6 weeks. Histological assessment was used to determine the area of granulation tissue around the foams, and the number of blood vessels within the granulation tissue was counted. The presence of Bioglass particles in the foams produced a sustained increase in the area of granulation tissue surrounding the foams. The number of blood vessels surrounding the neat foams was reduced after 2 weeks of implantation; however, compression-molded foams containing Bioglass after 4 and 6 weeks of implantation had significantly more blood vessels surrounding the foams compared with foams containing no Bioglass at the same time points. These results indicate that composite polymer foam scaffolds containing Bioglass particles retain granulation tissue and blood vessels surrounding the implanted foams. The use of this polymer composite for tissue engineering scaffolds might provide a novel approach for ensuring adequate vascular supply to the implanted device.

Topics
  • impedance spectroscopy
  • polymer
  • phase
  • experiment
  • glass
  • glass
  • composite
  • compression molding