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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Fernandes, Mh
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2023Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cellscitations
- 2023Full physicochemical and biocompatibility characterization of a supercritical CO2 sterilized nano-hydroxyapatite/chitosan biodegradable scaffold for periodontal bone regenerationcitations
- 2022Fabrication of a biodegradable and cytocompatible magnesium/ nanohydroxyapatite/fluorapatite composite by upward friction stir processing for biomedical applicationscitations
- 202145S5 Bioglass-Derived Glass-Ceramic Scaffolds Containing Niobium Obtained by Gelcasting Methodcitations
- 2020Femtosecond laser microstructuring of alumina toughened zirconia for surface functionalization of dental implantscitations
- 2019Influence of PLLA/PCL/HA Scaffold Fiber Orientation on Mechanical Properties and Osteoblast Behaviorcitations
- 2019Inhibitory Effect of 5-Aminoimidazole-4-Carbohydrazonamides Derivatives Against Candida spp. Biofilm on Nanohydroxyapatite Substratecitations
- 2018Processing, characterization, and in vivo evaluation of poly (L-lactic acid)-fish gelatin electrospun membranes for biomedical applicationscitations
- 2018Femtosecond laser impact on calcium phosphate bioceramics assessed by micro-Raman spectroscopy and osteoblastic behaviourcitations
- 2018Development of bioactive tellurite-lanthanide ions-reinforced hydroxyapatite composites for biomedical and luminescence applicationscitations
- 2018Highly porous 45S5 bioglass-derived glass-ceramic scaffolds by gelcasting of foamscitations
- 2018Micropatterned Silica Films with Nanohydroxyapatite for Y-TZP Implantscitations
- 2017Incorporation of glass-reinforced hydroxyapatite microparticles into poly(lactic acid) electrospun fibre mats for biomedical applicationscitations
- 2016Biodegradation, biocompatibility, and osteoconduction evaluation of collagen-nanohydroxyapatite cryogels for bone tissue regenerationcitations
- 2016Effect of Sterilization Methods on Electrospun Poly(lactic acid) (PLA) Fiber Alignment for Biomedical Applicationscitations
- 2015Smart electroconductive bioactive ceramics to promote in situ electrostimulation of bonecitations
- 2015Novel cerium doped glass-reinforced hydroxyapatite with antibacterial and osteoconductive properties for bone tissue regenerationcitations
- 2014Modulation of human dermal microvascular endothelial cell and human gingival fibroblast behavior by micropatterned silica coating surfaces for zirconia dental implant applicationscitations
- 2014Processing strategies for smart electroconductive carbon nanotube-based bioceramic bone graftscitations
- 2013Development and characterization of lanthanides doped hydroxyapatite composites for bone tissue applicationcitations
- 2012Development and Characterization of Ag2O-Doped ZnLB Glasses and Biological Assessment of Ag2O-ZnLB-Hydroxyapatite Compositescitations
- 2010Evaluation of human osteoblastic cell response to plasma-sprayed silicon-substituted hydroxyapatite coatings over titanium substratescitations
- 2010New titanium and titanium/hydroxyapatite coatings on ultra-high-molecular-weight polyethylene-in vitro osteoblastic performancecitations
- 2009Assessment of the osteoblastic cell response to a zinc glass reinforced hydroxyapatite composite (Zn-GRHA)citations
- 2005In vitro studies of calcium phosphate glass ceramics with different solubility with the use of human bone marrow cellscitations
Places of action
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article
In vitro studies of calcium phosphate glass ceramics with different solubility with the use of human bone marrow cells
Abstract
Two glass ceramics in the CaO-P2O5-MgO System with the incorporation of K2O or TiO2 oxides were prepared with the goal of using them as potential bone graft substitutes. The incorporation of TiO2 and K2O led to the preparation of specific crystalline phases in the structure of the glass ceramics, which show different degrees of biodegradation. In fact, the 45CaO-45P(2)O(5)-5MgO-5K(2)O has been previously demonstrated to be much more soluble in aqueous solutions than the 45CaO-37P(2)O(5)-5MgO-13TiO(2) glass ceramic. The in vitro biological activity of the two calcium phosphate glass ceramics was studied with the use of human bone marrow osteoblast cell cultures maintained for 28 days, and seeded materials were assessed for cell proliferation and function. The Ti-containing glass ceramic showed a stable surface throughout the culture time, on macroscopic and SEM observation. Osteoblast cells proliferated gradually, especially during the third week, with a high alkaline phosphatase activity and formation of a mineralized matrix. On SEM observation, attached cells appeared with a spread-polygonal morphology typical of the osteoblast cells, with extensive cell-to-cell contact. Cell behavior on the seeded material was similar to that found on cultures performed on tissue-culture-grade polystyrene; except for the presence of lower cell numbers during the first 2 weeks. By contrast, the K-containing glass ceramic showed a highly instable surface with dissolution/precipitation processes occurring throughout the culture time. Few cells adhered to the material surface, and subsequent proliferation was also hindered, especially from the first week onwards. Cell numbers were significantly lower than those observed in the Ti-containing glass ceramic during most of the incubation time. Results suggest that the different in vitro biological behavior of these two glass ceramics is mainly due to the significant differences in the surface degradation rate, which is directly correlated to the chemical composition of the mother glass. (c) 2005 Wiley Periodicals, Inc.