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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bonfield, W.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2012Cobalt-based orthopaedic alloys: Relationship between forming route, microstructure and tribological performance
- 2005In vivo assessment of hydroxyapatite and silicate-substituted hydroxyapatite granules using an ovine defect model
- 2004Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivocitations
- 2003Calcium phosphate coatings obtained by Nd : YAG laser cladding: Physicochemical and biologic propertiescitations
- 2003Comparison of sintering and mechanical properties of hydroxyapatite and silicon-substituted hydroxyapatite
- 2002Characterization of new acrylic bone cements prepared with oleic acid derivativescitations
- 2002Preparation and characterization of magnesium/carbonate co-substituted hydroxyapatitescitations
- 2002Anisotropic mechanical properties of oriented HAPEX™citations
- 2002Friction and wear of hydroxyapatite reinforced high density polyethylene against the stainless steel counterfacecitations
- 2002Effect of silicon substitution on the sintering and microstructure of hydroxyapatite
- 2001Production of calcium phosphate coatings on Ti6Al4V obtained by Nd : yttrium-aluminum-garnet laser cladding
- 2001Effect of powder characteristics on the sinterability of hydroxyapatite powderscitations
- 2001Calcining influence on the powder properties of hydroxyapatitecitations
- 2001Particle size effects on apatite-wollastonite glass crystallisation
- 2000Dynamic mechanical characterization of hydroxyapatite reinforced polyethylene: Effect of particle sizecitations
- 2000Analysis of apatite layers on glass-ceramic particulate using FTIR and FT-Raman spectroscopy
- 2000Influence of phase purity on the in vivo response to hydroxyapatite
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article
Ultrastructural comparison of dissolution and apatite precipitation on hydroxyapatite and silicon-substituted hydroxyapatite in vitro and in vivo
Abstract
Recent histological studies have demonstrated that the substitution of silicate ions into hydroxyapatite (HA) significantly increases the rate of bone apposition to HA implants. The enhanced bioactivity of silicon-substituted HA (Si-HA) over pure HA has been attributed to the effect of silicate ions in accelerating dissolution. In the present study, high-resolution transmission electron microscopy (HR-TEM) was employed to compare dissolution of HA and Si-HA in an acellular simulated body fluid (SBF) to dissolution in an in vivo model. HR-TEM observations confirmed a difference in morphology of apatite precipitates in vivo and in SBF: apatite deposits were platelike in vivo and nodular in SBF. Compositional mapping suggested that preferential dissolution of silicon from the implant promotes the nucleation of carbonate apatite around the implant. The in vivo findings illustrated an absence of dissolution at the bone-HA or Si-HA interface, whereas dissolution was extensive from within the implant. The amount of dissolution in acellular SBF was similar to dissolution from within the implant, although the site at which the dissolution nucleates was different: dissolution predominates at the crystallite surfaces in SBF, whereas grain boundary dissolution predominates in vivo. These findings suggest that proteins in the in vivo milieu modify the processes of dissolution from the implant. (C) 2004 Wiley Periodicals, Inc.