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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Guillaume, Sophie M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Metal-catalyzed stereoselective ring-opening polymerization of functional β-lactones: methylene-alkoxy-fluorinated polyhydroxyalkanoates unveil the role of non-covalent interactionscitations
- 2024Ring-opening (co)polymerization of chiral seven-membered lactones mediated by achiral yttrium catalysts: Insights into the catalyst stereocontrol by mass spectrometrycitations
- 2024Phosphorus-containing stereocontrolled polyhydroxyalkanoates by yttrium-mediated ring-opening copolymerization of β-lactonescitations
- 2023Chemistry that allows plastic recyclingcitations
- 2022Polythioesters Prepared by Ring-Opening Polymerization of Cyclic Thioesters and Related Monomerscitations
- 2022Upgrading Toughness and Glass Transition Temperature of Polydicyclopentadiene Upon Addition of Styrene-Ethylene-Butylene-Styrene Thermoplastic Elastomercitations
- 2022Tacticity Control of Cyclic Poly(3-Thiobutyrate) Prepared by Ring-Opening Polymerization of Racemic beta-Thiobutyrolactonecitations
- 2020Ring-opening (co)polymerization of six-membered substituted delta-valerolactones with alkali metal alkoxidescitations
- 2020Recent Advances in Metal-Mediated Stereoselective Ring-Opening Polymerization of Functional Cyclic Esters towards Well-defined Poly(hydroxy acid)s: From Stereoselectivity to Sequence‐Controlcitations
- 2018Evaluation of band-selective HSQC and HMBC Methodological validation on the cyclosporin cyclic peptide and application for poly(3-hydroxyalkanoate)s stereoregularity determinationcitations
- 2017Tuning the properties of α,ω-bis(trialkoxysilyl) telechelic copolyolefins from ruthenium-catalyzed chain-transfer ring-opening metathesis polymerization (ROMP)citations
- 2016Poly(trimethylene carbonate)/Poly(malic acid) Amphiphilic Diblock Copolymers as Biocompatible Nanoparticlescitations
- 2016New Linear and Star-Shaped Thermogelling Poly([ R ]-3-hydroxybutyrate) Copolymerscitations
- 2015Syndioselective ring-opening polymerization and copolymerization of trans-1,4-cyclohexadiene carbonate mediated by achiral metal- and organo-catalystscitations
- 2015Beyond Stereoselectivity, Switchable Catalysis: Some of the Last Frontier Challenges in Ring-Opening Polymerization of Cyclic Esterscitations
- 2015Ethylene carbonate/cyclic ester random copolymers synthesized by ring-opening polymerizationcitations
- 2014From Syndiotactic Homopolymers to Chemically Tunable Alternating Copolymers: Highly Active Yttrium Complexes for Stereoselective Ring-Opening Polymerization of β-Malolactonatescitations
- 2014Synthesis and polymerization of cyclobutenyl-functionalized polylactide and polycaprolactone: a consecutive ROP/ROMP route towards poly(1,4-butadiene)-g-polyesterscitations
- 2014From glycidyl carbonate to hydroxyurethane sidegroups in alternating fluorinated copolymerscitations
- 2013Organometallic strontium borohydrides - synthesis, catalytic studies, and DFT calculationscitations
- 2013Poly(hydroxyalkanoate) Block or Random Copolymers of β-Butyrolactone and Benzyl β-Malolactone: A Matter of Catalytic Tuning.citations
Places of action
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article
Poly(trimethylene carbonate)/Poly(malic acid) Amphiphilic Diblock Copolymers as Biocompatible Nanoparticles
Abstract
International audience ; Amphiphilic polycarbonate-poly(hydroxyalkanoate) diblock copolymers, namely, poly(trimethylene carbonate) (PTMC)-b-poly(β-malic acid) (PMLA), are reported for the first time. The synthetic strategy relies on commercially available catalysts and initiator. The controlled ring-opening polymerization (ROP) of trimethylene carbonate (TMC) catalyzed by the organic guanidine base 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), associated with iPrOH as an initiator, provided iPrO-PTMC-OH, which served as a macroinitiator in the controlled ROP of benzyl β-malolactonate (MLABe) catalyzed by the neodymium triflate salt (Nd(OTf)3 ). The resulting hydrophobic iPrO-PTMC-b-PMLABe-OH copolymers were then hydrogenolyzed into the parent iPrO-PTMC-b-PMLA-OH copolymers. A range of well-defined copolymers, featuring different sizes of segments (Mn,NMR up to 9300 g mol(-1) ; ÐM =1.28-1.40), were thus isolated in gram quantities, as evidenced by NMR spectroscopy, size exclusion chromatography, thermogravimetric analysis, differential scanning calorimetry, and contact angle analyses. Subsequently, PTMC-b-PMLA copolymers with different hydrophilic weight fractions (11-75 %) self-assembled in phosphate-buffered saline upon nanoprecipitation into well-defined nano-objects with Dh =61-176 nm, a polydispersity index .25, and a negative surface charge, as characterized by dynamic light scattering and zeta-potential analyses. In addition, these nanoparticles demonstrated no significant effect on cell viability at low concentrations, and a very low cytotoxicity at high concentrations only for PTMC-b-PMLA copolymers exhibiting hydrophilic fractions over 47 %, thus illustrating the potential of these copolymers as promising nanoparticles