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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Yamauchi, Yusuke
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Dealloying Strategies for Mesoporous AuCu Nanoparticles: Impact on Internal Metallic Structure and Electrocatalytic Performancecitations
- 2024Selection of Fe as a barrier for manufacturing low-cost MgB2 multifilament wires - Advanced microscopy study between Fe and B reactioncitations
- 2023Weak Bonds, Strong Effectscitations
- 2023Flexible Nanoarchitectonics for Biosensing and Physiological Monitoring Applicationscitations
- 2023Mesoporous multimetallic nanospheres with exposed highly entropic alloy sitescitations
- 2023High entropy alloying strategy for accomplishing quintuple-nanoparticles grafted carbon towards exceptional high-performance overall seawater splittingcitations
- 2022Multifunctional materials for photo-electrochemical water splittingcitations
- 2022Plasma-Induced Nanocrystalline Domain Engineering and Surface Passivation in Mesoporous Chalcogenide Semiconductor Thin Filmscitations
- 2022Efficient lithium-ion storage using a heterostructured porous carbon framework and its in situ transmission electron microscopy studycitations
- 2021Self-templated fabrication of hierarchical hollow manganese-cobalt phosphide yolk-shell spheres for enhanced oxygen evolution reactioncitations
- 2020Photodegradation Activity of Poly(ethylene oxide-b-<i>ε</i>-caprolactone)-Templated Mesoporous TiO<sub>2</sub> Coated with Au and Ptcitations
- 2020Holey assembly of two-dimensional iron-doped nickel-cobalt layered double hydroxide nanosheets for energy conversion applicationcitations
- 2020Potassium-Ion Storage in Cellulose-Derived Hard Carboncitations
- 2019Reduced Graphene Oxide (rGO) Prepared by Metal-Induced Reduction of Graphite Oxidecitations
- 2019Enhancement of thermoelectric properties of La-doped SrTiO <sub>3</sub> bulk by introducing nanoscale porositycitations
- 2018Graphene-oxide-loaded superparamagnetic iron oxide nanoparticles for ultrasensitive electrocatalytic detection of microRNAcitations
- 2017Self-assembly of polymeric micelles made of asymmetric polystyrene-b-polyacrylic acid-b-polyethylene oxide for the synthesis of mesoporous nickel ferritecitations
- 2017Nano-micro-porous skutterudites with 100% enhancement in ZT for high performance thermoelectricitycitations
- 2016Cyano-Bridged Trimetallic Coordination Polymer Nanoparticles and Their Thermal Decomposition into Nanoporous Spinel Ferromagnetic Oxidescitations
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article
Graphene-oxide-loaded superparamagnetic iron oxide nanoparticles for ultrasensitive electrocatalytic detection of microRNA
Abstract
We report the electrocatalytic activity of a new class of superparamagnetic nanoparticles, graphene-oxide-loaded iron oxide (GO/IO hybrid material), towards the reduction of ruthenium hexaammine(III) chloride (Ru(NH3)6]<sup>3+</sup>, RuHex). Leveraging the electrocatalytic activity of the GO/IO hybrid material and the signal enhancement capacity of [Ru(NH<sub>3</sub>)<sub>6</sub>]<sup>3+</sup>/[Fe(CN)<sub>6</sub>]<sup>3−</sup> in an electrocatalytic cycle, an ultrasensitive and specific electrochemical sensor was developed for the detection of cancer-related microRNA (miRNA). Using the direct affinity interaction between RNA and graphene oxide, magnetically isolated and purified target miRNA were directly adsorbed onto a screen-printed electrode modified with the GO/IO hybrid material. The detection was enabled by chronocoulometric (CC) readout of charge-compensating [Ru(NH<sub>3</sub>)<sub>6</sub>]<sup>3+</sup> followed by an enhancement in CC charge display through the Ru(NH<sub>3</sub>)<sub>6</sub>]<sup>3+</sup>/[Fe(CN)<sub>6</sub>]<sup>3− </sup>system. We demonstrate an excellent limit of detection of 1.0 fM by accurately detecting miR-21 in synthetic samples and showcase its clinical utility in ovarian cancer cell lines with high sensitivity (ten cells) and good reproducibility (% RSD=<5 %, for <i>n</i>=3).