| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Carraro, Francesco
Graz University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Polymorphism and orientation control of copper-dicarboxylate metal-organic framework thin films through vapour- and liquid-phase growthcitations
- 2023Targeting telomerase utilizing zeolitic imidazole frameworks as non-viral gene delivery agents across different cancer cell typescitations
- 2023Identifying the Internal Network Structure of a New Copper Isonicotinate Thin-Film Polymorph Obtained via Chemical Vapor Depositioncitations
- 2022Combining a Genetically Engineered Oxidase with Hydrogen-Bonded Organic Frameworks (HOFs) for Highly Efficient Biocompositescitations
- 2022Self‐Assembly of Oriented Antibody‐Decorated Metal–Organic Framework Nanocrystals for Active‐Targeting Applicationscitations
- 2022Self‐Assembly of Oriented Antibody‐Decorated Metal–Organic Framework Nanocrystals for Active‐Targeting Applicationscitations
- 2021MOFs and Biomacromolecules for Biomedical Applicationscitations
- 2021Self-Assembly of Oriented Antibody-Decorated Metal–Organic Framework Nanocrystals for Active-Targeting Applicationscitations
- 2021Metal-Organic Framework-Based Enzyme Biocompositescitations
- 2020Phase dependent encapsulation and release profile of ZIF-based biocompositescitations
- 2020Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Sizecitations
- 2018Nano-structured aluminum surfaces for dropwise condensationcitations
- 2018Aerosol Synthesis of N and N-S Doped and Crumpled Graphene Nanostructurescitations
- 2017Hybrid Organic/Inorganic Perovskite-Polymer Nanocompositescitations
- 2015Fast One-Pot Synthesis of MoS2/Crumpled Graphene p-n Nanonjunctions for Enhanced Photoelectrochemical Hydrogen Productioncitations
Places of action
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article
Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size
Abstract
<p>Zeolitic imidazolate framework (ZIF) biocomposites show the capacity to protect and deliver biotherapeutics. To date, the progress in this research area is based on laboratory batch methods. Now, the first continuous flow synthetic method is presented for the encapsulation of a model protein (bovine serum albumin, BSA) and a clinical therapeutic (α1-antitrypsin, AAT) in ZIF-8. The in situ kinetics of nucleation, growth, and crystallization of BSA@ZIF-8 were studied by small-angle X-ray scattering. By controlling the injection time of ethanol, the particle growth could be quenched by ethanol-induced crystallization from amorphous particles to ZIF-8 crystals. The particle size of the biocomposite was tuned in the 40–100 nm range by varying residence time prior to introduction of ethanol. As a proof-of-concept, this procedure was used for the encapsulation of AAT in ZIF-8. Upon release of the biotherapeutic from the composite, the trypsin inhibitor function of AAT was preserved.</p>