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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Asherson, Philip
King's College London
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2019Atypical functional connectivity in adolescents and adults with persistent and remitted ADHD during a cognitive control taskcitations
- 2017Association of preterm birth with ADHD-like cognitive impairments and additional subtle impairments in attention and arousal malleabilitycitations
- 2016Modifiable Arousal in Attention-Deficit/Hyperactivity Disorder and Its Etiological Association With Fluctuating Reaction Timescitations
- 2013Genetic analysis of reaction time variabilitycitations
- 2002Expression of the dopamine transporter gene is regulated by the 3'UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCT.citations
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article
Expression of the dopamine transporter gene is regulated by the 3'UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCT.
Abstract
Genetic association studies provide considerable evidence that the 10-repeat allele of a variable number tandem repeat (VNTR) in the 3'-untranslated region (3'-UTR) of the dopamine transporter gene (DAT1) is associated with a range of psychiatric phenotypes, most notably, attention deficit hyperactivity disorder. The mechanism for this association is not yet understood, although several lines of evidence implicate variation in gene expression. In this study, we measured DAT1 messenger RNA levels in cerebellum, temporal lobe, and lymphocytes using quantitative real-time reverse-transcription polymerase chain reaction. Relative to a set of four control housekeeping genes (beta-actin, GAPD, ribosomal 18S, and beta2-microglobulin) we observed that increased levels of DAT1 expression were associated with the number of 10-repeat alleles. These data provide direct evidence that the VNTR, or another polymorphism in linkage disequilibrium with the VNTR, is involved in regulating expression of this gene. (C) 2002 Wiley-Liss, Inc.