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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Macgregor, Melanie
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Electrochemical behavior of oxazoline-based plasma polymers for biosensing applicationscitations
- 2022Organic Monolayers on Si(211) for Triboelectricity Generationcitations
- 2022Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patchescitations
- 2021Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensorscitations
- 2019Nanotopography-Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activationcitations
- 2019Perspective on Plasma Polymers for Applied Biomaterials Nanoengineering and the Recent Rise of Oxazolinescitations
- 2018Binding of Nanoparticles to Aminated Plasma Polymer Surfaces is Controlled by Primary Amine Density and Solution pHcitations
- 2016A comparative assessment of nanoparticulate and metallic silver coated dressingscitations
- 2016Plasma deposition of organic polymer films for solar cell applicationscitations
- 2015Properties and reactivity of polyoxazoline plasma polymer filmscitations
Places of action
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article
Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensors
Abstract
<p>Electrochemical immunosensors are an emerging technology for the fast, sensitive, and reliable diagnosis of diseases from bodily fluids. These sensors work by detecting a change in current upon analyte binding to an immuno-functionalized electrode. Current methods of electrode functionalization are lengthy processes involving self-assembled monolayer formation and wet chemistry biofunctionalization. Herein, thin films deposited from the plasma phase of oxazoline precursors are investigated and optimized as an alternative approach for electrode functionalization. The plasma-enabled method has the advantage of being substrate independent and allows the spontaneous binding of biomolecules in physiological buffer. Surface sensitive analysis techniques are employed to characterize the thickness, reactivity, and stability of the thin films before investigating their electrochemical properties on indium tin oxide and gold electrodes including the feasibility to reduce charge transfer resistance with gold nanoparticles. Last, these films are employed to develop an immunosensor for the detection of free epithelial cell adhesion molecule with a limit of detection of 8.7 ng mL<sup>−1</sup>.</p>