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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Ajalloueian, Fatemeh
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2024Effect of ethylene oxide and gamma sterilization on surface texture of films and electrospun poly(ε-caprolactone-co-p-dioxanone) (PCLDX) scaffolds
- 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications:A focus on silk fibroin-based scaffoldscitations
- 2021Physical and Oxidative Stability of Low-Fat Fish Oil-in-Water Emulsions Stabilized with Black Soldier Fly (Hermetia illucens) Larvae Protein Concentratecitations
- 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applicationscitations
- 2019Thread-Like Radical-Polymerization via Autonomously Propelled (TRAP) Botscitations
- 2018Fabrication, characterization, and biocompatibility assessment of a novel elastomeric nanofibrous scaffold: A potential scaffold for soft tissue engineeringcitations
- 2018Fabrication, characterization, and biocompatibility assessment of a novel elastomeric nanofibrous scaffold: A potential scaffold for soft tissue engineeringcitations
- 2017Rheological properties of agar and carrageenan from Ghanaian red seaweedscitations
- 2015Investigation of Human Mesenchymal Stromal Cells Cultured on PLGA or PLGA/Chitosan Electrospun Nanofiberscitations
Places of action
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article
Thread-Like Radical-Polymerization via Autonomously Propelled (TRAP) Bots
Abstract
Micromotor-mediated synthesis of thread-like hydrogel microstructures in an aqueous environment is presented. The study utilizes a catalytic micromotor assembly (owing to the presence of a Pt layer), with an on-board chemical reservoir (i.e., polymerization mixture), toward thread-like radical-polymerization via autonomously propelled bots (i.e., TRAP bots). Synergistic coupling of catalytically active Pt layer, together with radical initiators (H 2 O 2 and FeCl 3 (III)), and PEGDA monomers preloaded into the TRAP bot, results in the polymerization of monomeric units into elongated thread-like hydrogel polymers coupled with self-propulsion. Interestingly, polymer generation via TRAP bots can also be triggered in the absence of hydrogen peroxide for cellular/biomedical application. The resulting polymeric hydrogel microstructures are able to entrap living cells (NIH 3T3 fibroblast cells), and are easily separable via a centrifugation or magnetic separation (owing to the presence of a Ni layer). The cellular biocompatibility of TRAP bots is established via a LIVE/DEAD assay and MTS cell proliferation assay (7 days observation). This is the first study demonstrating real-time in situ hydrogel polymerization via an artificial microswimmer, capable of enmeshing biotic/abiotic microobjects in its reaction environment, and lays a strong foundation for advanced applications in cell/tissue engineering, drug delivery, and cleaner technologies.