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Ghanami, R. Cheikh Al
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article
Biodegradable thermoresponsive microparticle dispersions for injectable cell delivery prepared using a single-step process
Abstract
The biodegradable thermoresponsive microparticle dispersions for injectable cell delivery were prepared by employing a single-step process promising for biomedical applications principally composed of PEG and PPG segments with a biodegradable core. The new biocompatible responsive polymers were synthesized by copolymerization of PEGMA in various monomer ratios, where the control of the initiator:monomer ratio (in ATRP) and chain-transfer agent (CTA):monomer ratios (in FRP) allowed control over molar mass were reported over a wide temperature range. The results of the experiment indicate that the thermoresponsive copolymers is also adaptable for specific cell-delivery and tissue-engineering applications, and can help to regulate PLGA degradation, or bioadhesive functionalities to mimic key features of the extracellular matrix, so as to promote cell cell contact and foster enhanced tissue generation.