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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Nielsen, Line Hagner
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 20233D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Deliverycitations
- 2019Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices
- 2019Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matricescitations
- 2019Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopycitations
- 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursorscitations
- 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursorscitations
- 2017Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumincitations
- 2016Triple co-culture cell model as an in vitro model for oral particulate vaccine systems
- 2015Stabilisation of amorphous furosemide increases the oral drug bioavailability in ratscitations
- 2013Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs.
- 2013Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to ratscitations
- 2013Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs.
Places of action
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article
3D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery
Abstract
During the past decades, microdevices have been evaluated as a means to overcome challenges within oral drug delivery, thus improving bioavailability. Fabrication of microdevices is often limited to planar or simple 3D designs. Therefore, this work explores how microscale stereolithography 3D printing can be used to fabricate radiopaque microcontainers with enhanced mucoadhesive geometries, which can enhance bioavailability by increasing gastrointestinal retention. Ex vivo force measurements suggest increased mucoadhesion of microcontainers with adhering features, such as pillars and arrows, compared to a neutral design. In vivo studies, utilizing planar x-ray imaging, show time dependent gastrointestinal location of microcontainers, whereas computed tomography scanning and cryogenic scanning electron microscopy reveal information about their spatial dynamics and mucosal interactions. For the first time, the effect of 3D microdevice modifications on gastrointestinal retention is traced in vivo, and the applied methods provide a much-needed approach for investigating the impact of device design on gastrointestinal retention. This article is protected by copyright. All rights reserved.