| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Kirby, Nigel
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2022A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarkingcitations
- 2022A round-robin approach provides a detailed assessment of biomolecular small-angle scattering data reproducibility and yields consensus curves for benchmarkingcitations
- 2021Shape of nanopores in track-etched polycarbonate membranescitations
- 2015Protic ionic liquids (PILs) nanostructure and physicochemical properties: development of high-throughput methodology for PIL creation and property screenscitations
- 2015Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromoleculescitations
- 2014Construction of DNA–polymer hybrids using intercalation interactionscitations
- 2014Particle evolution in Mg-Zn-Zr alloy processed by integrated extrusion and equal channel angular pressingcitations
- 2013Mesoporous europo-gadolinosilicate nanoparticles as bimodal medical imaging agents and a potential theranostic platformcitations
- 2012Protic ionic liquids with fluorous anions: physicochemical properties and self-assembly nanostructurecitations
Places of action
| Organizations | Location | People |
|---|
article
Mesoporous europo-gadolinosilicate nanoparticles as bimodal medical imaging agents and a potential theranostic platform
Abstract
<p>The mesoporous structure of sol-gel prepared gadolinium and europium doped silicate nanoparticles has been found to be highly dependent on the formulated composition, with synthesised samples displaying both disordered and hexagonally ordered mesoporous packing symmetry. The degree of pore ordering within the nanoparticles has a strong correlation with the total lanthanide (Gd<sup>3+</sup> and Eu<sup>3+</sup>) concentration. The gadolinosilicates are excellent magnetic resonance imaging (MRI) longitudinal (T<sub>1</sub>) agents. The longitudinal relaxivity (r<sub>1</sub>) and transverse (r<sub>2</sub>) relaxivity, a measure of MRI contrast agent efficiency, were up to four times higher than the clinically employed Omniscan (gadodiamide); with r<sub>1</sub> up to 20.6 s<sup>-1</sup> mM<sup>-1</sup> and r<sub>2</sub> of 66.2 s<sup>-1</sup> mM<sup>-1</sup> compared to 5.53 and 4.64 s<sup>-1</sup> mM<sup>-1</sup>, respectively, for Omniscan. In addition, the europium content of all the samples studied is below the self-quenching limit, which results in a strong luminescence response from the nanoparticles on excitation at 250 nm. The Eu-Gd silicate nanoparticles act as bimodal imaging agents for MRI and luminescence. These mesoporous nanoparticles also have the potential to serve as encapsulation and controlled release matrices for pharmaceuticals. They are therefore a promising multimodal theranostic platform.</p>