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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zhang, Hong
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2024Helical interfacial modulation for perovskite photovoltaicscitations
- 2024Confined Flash Printing and Synthesis of Stable Perovskite Nanofilms under Ambient Conditions
- 2023Efficient, Near‐Infrared Light‐Induced Photoclick Reaction Enabled by Upconversion Nanoparticlescitations
- 2023Efficient, Near‐Infrared Light‐Induced Photoclick Reaction Enabled by Upconversion Nanoparticlescitations
- 2023Structure‐guided Capacitance Relationships in Oxidized Graphene Porous Materials Based Supercapacitors
- 2022Morphologic and Genomic Characteristics of Breast Cancers Occurring in Individuals with Lynch Syndromecitations
- 2022Tuning phase separation morphology in blend thin films using well-defined linear (multi)block copolymerscitations
- 2016A Series of Pyrene-Substituted Silicon Phthalocyanines as Near-IR Sensitizers in Organic Ternary Solar Cellscitations
- 2016A hyperbranched dopamine-containing PEG-based polymer for the inhibition of α-synuclein fibrillationcitations
- 2013Simulating lattice image of suspended graphene taken by Helium ion microscopy
Places of action
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article
Efficient, Near‐Infrared Light‐Induced Photoclick Reaction Enabled by Upconversion Nanoparticles
Abstract
<jats:title>Abstract</jats:title><jats:p>Photoclick reactions combine the selectivity of classical click chemistry with the high precision and spatiotemporal control afforded by light, finding diverse utility in surface customization, polymer conjugation, photocross‐linking, protein labeling, and bioimaging. Nonetheless, UV light, pivotal in prevailing photoclick reactions, poses issues, especially in biological contexts, due to its limited tissue penetration and cell‐toxic nature. Herein, a reliable and versatile strategy of activating the photoclick reactions of 9,10‐phenanthrenequinones (<jats:bold>PQ</jats:bold>s) with electron‐rich alkenes (<jats:bold>ERA</jats:bold>s) with near infrared (NIR) light transduced by spectrally and structurally customized upconversion nanoparticles (<jats:bold>UCNP</jats:bold>s) is introduced. Under NIR irradiation, the <jats:bold>UCNP</jats:bold>s become UV/blue nanoemitters uniformly distributed in the reaction system. Enabled by the customized <jats:bold>UCNP</jats:bold>s, 800 or 980 nm light effectively activates the photocycloaddition reactions via radiative energy transfer in both general and triplet–triplet energy transfer (TTET)‐mediated <jats:bold>PQ‐ERA</jats:bold> systems. In particular, the novel sandwich structure <jats:bold>UCNP</jats:bold>s achieve the click reaction with up to 76% production yield in 10 min under NIR light irradiation. Meanwhile, the tricky side effect of photoclick product absorption‐induced quenching is successfully circumvented from the fine‐tuning of the upconversion spectrum. Moreover, through‐tissue irradiation experiments, the authors show that the <jats:bold>UCNP</jats:bold>‐<jats:bold>PQ‐ERA</jats:bold> reaction unlocks the full potential of photoclick reactions for in vivo applications.</jats:p>