| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Dawson, Jonathan
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023Branched copolymer surfactants impart thermoreversible gelation to LAPONITE® gels †
- 2023Branched copolymer surfactants impart thermoreversible gelation to LAPONITE® gels
- 2022Determination of protoplast growth properties using quantitative single-cell tracking analysiscitations
- 2021Nanocomposite clay-based bioinks for skeletal tissue engineeringcitations
- 2020Growth‐factor free multicomponent nanocomposite hydrogels that stimulate bone formationcitations
- 2020Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localizationcitations
- 2020Nanoclay-polyamine composite hydrogel for topical delivery of nitric oxide gas via innate gelation characteristics of laponitecitations
- 2020Nanoclay-polyamine composite hydrogel for topical delivery of nitric oxide gas via innate gelation characteristics of laponitecitations
- 2020Nanoclay-based 3D printed scaffolds promote vascular ingrowth ex vivo and generate bone mineral tissue in vitro and in vivo
- 2019Printing bone in a gel: using nanocomposite bioink to print functionalised bone scaffoldscitations
- 2019Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinkscitations
- 2018Clay nanoparticles for regenerative medicine and biomaterial designcitations
- 2013A tissue engineering strategy for the treatment of avascular necrosis of the femoral headcitations
Places of action
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article
Growth‐factor free multicomponent nanocomposite hydrogels that stimulate bone formation
Abstract
Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors represent a major opportunity for an aging world population. A co‐assembling system that integrates hyaluronic acid tyramine (HA‐Tyr ), bioactive peptide amphiphiles (GHK‐Cu<sup>2+</sup>), and Laponite (Lap ) to engineer hydrogels with physical, mechanical, and biomolecular signals that can be tuned to enhance bone regeneration is reported. The central design element of the multicomponent hydrogels is the integration of self‐assembly and enzyme‐mediated oxidative coupling to optimize structure and mechanical properties in combination with the incorporation of an osteo‐ and angio‐promoting segments to facilitate signaling. Spectroscopic techniques are used to confirm the interplay of orthogonal covalent and supramolecular interactions in multicomponent hydrogel formation. Furthermore, physico‐mechanical characterizations reveal that the multicomponent hydrogels exhibit improved compressive strength, stress relaxation profile, low swelling ratio, and retarded enzymatic degradation compared to the single component hydrogels. Applicability is validated in vitro using human mesenchymal stem cells and human umbilical vein endothelial cells, and in vivo using a rabbit maxillary sinus floor reconstruction model. Animals treated with the HA‐Tyr‐HA‐Tyr‐GHK‐Cu<sup>2+</sup> hydrogels exhibit significantly enhanced bone formation relative to controls including the commercially available Bio‐Oss.