| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Truckenmüller, Roman
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2023Direct deep UV lithography to micropattern PMMA for stem cell culturecitations
- 2023Polymer film-based microwell array platform for long-term culture and research of human bronchial organoidscitations
- 2023Polymer film-based microwell array platform for long-term culture and research of human bronchial organoidscitations
- 2022Assessment of Cell-Material Interactions in Three Dimensions through Dispersed Coaggregation of Microsized Biomaterials into Tissue Spheroidscitations
- 2021Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicinecitations
- 2021Thin fluorinated polymer film microcavity arrays for 3D cell culture and label-free automated feature extractioncitations
- 2020Intestinal Organoid Culture in Polymer Film-Based Microwell Arrayscitations
- 2019A Microcavity Array-Based 3D Model System of the Hematopoietic Stem Cell Nichecitations
- 20163D high throughput screening and profiling of embryoid bodies in thermoformed microwell platescitations
- 2016Independent effects of the chemical and microstructural surface properties of polymer/ceramic composites on proliferation and osteogenic differentiation of human MSCscitations
- 2014Biofunctional Micropatterning of Thermoformed 3D Substratescitations
- 2012Fabrication of cell container arrays with overlaid surface topographiescitations
- 2012Fabrication of cell container arrays with overlaid surface topographiescitations
- 2011Thermoforming of film-based biomedical microdevicescitations
Places of action
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article
Biofunctional Micropatterning of Thermoformed 3D Substrates
Abstract
Mimicking the in vivo microenvironment of cells is a challenging task in engineering in vitro cell models. Surface functionalization is one of the key components providing biochemical cues to regulate the interaction between cells and their substrate. In this study, two different approaches yield biofunctional surface patterns on thermoformed polymer films. The first strategy based on maskless projection lithography enables the creation of grayscale patterns of biological ligands with a resolution of 7.5 µm in different shapes on a protein layer adsorbed on a polymer film. In the second strategy, polymer films are micropatterned with different functional groups via chemical vapor deposition polymerization. After thermoforming, both types of pattern can be decorated with proteins either by affinity binding or covalent coupling. The 3d microstructures retain the biofunctional patterns as demonstrated by selective cell adhesion and growth of l929 mouse fibroblasts. This combination of functional micropatterning and thermoforming offers new perspectives for the design of 3d cell culture platforms.