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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bianchi, Claudia L.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2024Cuttng-Edge Perovskite Photocatalysts synthesized by Ultrasound: A Game-Changer in Air Pollution Control
- 2024Visible light active Ag@SrTiO3: a powerful photocatalyst for NOx degradationcitations
- 2023Ternary Polyaniline@Bi2O3-BiOCl Nanocomposites as Innovative Highly Active Photocatalysts for the Removal of the Dye under Solar Light Irradiationcitations
- 2023Investigating the synergistic effect of decoration and doping in silver/strontium titanate for air remediation
- 2023Loofah-based materials for pH-driven selective adsorption of multi-dyes solutions
- 2023One-pot synthesis of Ag-modified SrTiO3: synergistic effect of decoration and doping for highly efficient photocatalytic NOx degradation under LEDcitations
- 2022Sustainable Solar Light Photodegradation of Diclofenac by Nano- and Micro-Sized SrTiO3citations
- 2022Revealing the stability of CuWO4/g-C3N4 nanocomposite for photocatalytic tetracycline degradation from the aqueous environment and DFT analysiscitations
- 2022Polyaniline-based compounds as sorbents and photoactive materials for environmental remediation: sunrise or sunset?
- 2021Polyaniline-oxide nanocomposites for environmental remediation : the role of the nature of the photocatalyst
- 2021Comparison of the photoactivity of several semiconductor oxides in floating aerogel and suspension systems towards the reduction of Cr(VI) under visible lightcitations
- 2021Photoreduction ability of aerogel self-floating materials loaded with different visible light responsive photocatalysts
- 2021Dark and light mediated NO2 abatement by TiO2- and WO3-polyaniline nanocomposites
- 2021Floating smart materials for water decontamination under solar light
- 2018Photocatalytic TiO2: From Airless Jet Spray Technology to Digital Inkjet Printingcitations
- 2018Photocatalytic Tio2 : From Airless Jet Spray Technology To Digital inkjet Printingcitations
- 2007Biomimetic hydroxyapatite-drug nanocrystals as potential bone substitutes with antitumor drug delivery propertiescitations
Places of action
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article
Biomimetic hydroxyapatite-drug nanocrystals as potential bone substitutes with antitumor drug delivery properties
Abstract
This Full Paper investigates the adsorption and desorption of the anticancer drugs cis-diamminedichloroplatinum(II) (CDDP, cisplatin) and the new platinum(II) complex di(ethylenediamineplatinum)medronate (DPM), as well as the clinically relevant bisphosphonate alendronate, towards two biomimetic synthetic HA nanocrystalline materials with either plate-shaped (HAps) or needle-shaped (HAns) morphologies and different chemico-physical properties. The adsorption and desorption kinetics are dependent on the specific properties of the drugs and the morphology of the HA nanoparticles. Adsorption of the platinum complexes occurs with retention of the nitrogen ligands but the chloride ligands of cisplatin are displaced. Despite their opposite charges, the negatively charged alendronate bisphosphonate and the positively charged aquated cisplatin are strongly adsorbed, while the neutral DPM complex shows lower affinity towards the negatively charged apatitic surface. The data suggest that adsorption of the two platinum complexes is driven by electrostatic attractions, while interaction between the alendronate and the HA surface takes place by ligand exchange in which the two phosphonate groups of the drug molecule replace two surface phosphate groups. Significantly, adsorption of positively charged hydrolysis species of cisplatin is more favored on the phosphate-rich HAns surface while adsorption of negatively charged alendronate is more favored on the calcium-rich HAps surface. The latter type of short-range electrostatic interactions also appear to dominate the desorption kinetics; consequently, drug release is greater for neutral DPM than for charged alendronate and aquated cisplatin. Moreover, while the release per unit area of charged species is the same for the two types of HAs, the release of DPM is faster from HAns, which is lower in surface calcium, than for HAps. Overall, this work demonstrates that the properties of HA nanocrystals can be modulated in such a way to produce HA/biomolecule conjugates tailored for ...