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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Khanbareh, Hamideh
University of Bath
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (19/19 displayed)
- 2024Porous Structure Enhances the Longitudinal Piezoelectric Coefficient and Electromechanical Coupling Coefficient of Lead-Free (Ba0.85Ca0.15)(Zr0.1Ti0.9)O3citations
- 2024Porous structure enhances the longitudinal piezoelectric coefficient and electromechanical coupling coefficient of lead‐free (Ba 0.85 Ca 0.15 )(Zr 0.1 Ti 0.9 )O 3citations
- 2024Temperature-Dependent Ferroelectric Properties and Aging Behavior of Freeze-Cast Bismuth Ferrite-Barium Titanate Ceramicscitations
- 2024Temperature-Dependent Ferroelectric Properties and Aging Behavior of Freeze-Cast Bismuth Ferrite–Barium Titanate Ceramicscitations
- 2024Exploring Lead-Free Materials for Screen-Printed Piezoelectric Wearable Devicescitations
- 2023Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Compositescitations
- 2022Innovative piezo-active composites and their structure - Property relationshipscitations
- 2022Piezoelectric materials and systems for tissue engineering and implantable energy harvesting devices for biomedical applicationscitations
- 2021Additively manufactured BaTiOcitations
- 2021Additively manufactured BaTiO3 composite scaffolds: a novel strategy for load bearing bone tissue engineering applicationscitations
- 2021Additively manufactured BaTiO3 composite scaffoldscitations
- 2020Harnessing Plasticity in an Amine-Borane as a Piezoelectric and Pyroelectric Flexible Filmcitations
- 2019Piezoelectric performance of PZT-based materials with aligned porosity::experiment and modellingcitations
- 2019Experimental studies on effective properties and related parameters of piezo-particulate composites
- 2019Piezo-active composites
- 2019Modified energy harvesting figures of merit for stress- and strain-driven piezoelectric systemscitations
- 2019Modelling of the composite structure formation during dielectrophoresis
- 2019Piezoelectric performance of PZT-based materials with aligned porosity:citations
- 2018Understanding the effect of porosity on the polarisation-field response of ferroelectric materialscitations
Places of action
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article
Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites
Abstract
Spinal cord injuries can cause permanent tissue damage with debilitating and lasting effects on patients. Electrical stimulation has been established as an effective approach for promoting neural regeneration. However, the clinical applicability of these techniques is limited by the necessity for wired connections and external power supplies, which increases risk of infection. Piezoelectric materials have the inherent ability to form electric surface potentials when subjected to a mechanical stress and can provide wireless electrical stimulation. However, current materials are not optimized for neurological applications as they are mechanically mismatched with neural tissue, and have poor biocompatibility. Further, reproducible systems for optimizing material design and stimulation paradigms have yet to be established. Here a new, advanced fabrication process to produce scalable, tuneable piezoelectric ceramic–polymer composites based on [K0.5Na0.5]NbO3 and polydimethylsiloxane is provided. It is demonstrated that these composites can be successfully utilized for the growth of neural stem cells, which are shown to survive, proliferate, retain stemness, and differentiate into their daughter populations. Neuronal differentiation appears to be preferred on poled substrates, in comparison to glass coverslips and unpoled substrates. It is shown that the composites can autonomously generate surface potentials, which opens new possibilities to study piezoelectrically induced electrical stimulation.