| People | Locations | Statistics |
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| Grohsjean, Alexander |
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| Falmagne, G. |
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| Erice, C. |
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| Hernandez, A. M. Vargas |
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| Leiton, A. G. Stahl |
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| Lipka, K. |
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| Pantaleo, F. |
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| Torterotot, L. |
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| Savina, M. |
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| Cerri, O. |
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| Jung, A. W. |
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| Chiarito, B. |
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| Sahin, M. O. |
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| Strong, G. |
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| Saradhy, R. |
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| Joshi, B. M. |
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| Kaynak, B. |
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| Barrera, C. Baldenegro |
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| Longo, Egidio |
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| Kolberg, Ted |
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| Ferguson, Thomas |
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| Leverington, Blake |
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| Haase, Fabian |
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| Heath, Helen F. |
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| Kokkas, Panagiotis |
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Piozzi, Antonella
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2023Rice husk ash as a green feedstock for the extraction of nano-silica and its application in the synthesis of an efficient solid biocatalyst
- 2020Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocompositescitations
- 2017Taurine grafting and collagen adsorption on PLLA films improve human primary chondrocyte adhesion and growthcitations
- 2016Flexible aliphatic poly(isocyanurate-oxazolidone) resins based on poly(ethylene glycol) diglycidyl ether and 4,4′-methylene dicyclohexyl diisocyanatecitations
- 2015Self-Assembly of catecholic moiety-containing cationic random acrylic copolymerscitations
- 2015Antimicrobial and antioxidant amphiphilic random copolymers to address medical device-centered infectionscitations
- 2014Biomimetic Polyurethanescitations
- 2014Partially sulfonated ethylene-vinyl alcohol copolymer as new substrate for 3,4-ethylenedioxythiophene vapor phase polymerizationcitations
- 2013Editorial of the special issue antimicrobial polymerscitations
- 2012A new approach for the preparation of hydrophilic poly(L-lactide) porous scaffold for tissue engineering by using lamellar single crystalscitations
- 2012Lipase Immobilization on Differently Functionalized Vinyl-Based Amphiphilic Polymers: Influence of Phase Segregation on the Enzyme Hydrolytic Activitycitations
- 2012Synthesis of biomimetic segmented polyurethanes as antifouling biomaterialscitations
- 2010Novel intrinsically antimicrobial polymers to control biofilm formation on medical devices
- 2010Synthesis and properties of block poly(ether-ester)s based on poly(ethylene oxide) and various hydrophobic segmentscitations
- 2010Polyurethane anionomers containing metal ions with antimicrobial properties: Thermal, mechanical and biological characterizationcitations
- 2009Antibiofilm properties of functionalized polyurethanes adsorbed with metal ions (Ag+, Cu2+, Zn2+, Al3+ and Fe3+)
- 2007Synthesis, characterization, and in vitro activity of antibiotic releasing polyurethanes to prevent bacterial resistancecitations
- 2007Staphylococcus epidermidis biofilm growth on polyurethanes is inhibited by the synergistic action of Dispersin B and cefamandole nafate.
- 2005Inhibition of Candida growth and biofilm formation on polyurethanes by fluconazole adsorption.citations
- 2004Inhibition of bacterial biofilm formation on polymer surfaces by a natural antimicrobial agent
- 2004Inhibition of biofilm formation in Gram-positive bacteria by a natural antimicrobial agent
- 2001CATALITIC ACTIVITY OF IMMOBILIZED FUMARASEcitations
- 2000Sulfation and preliminary biological evaluation of ethylene-vinyl alcohol copolymerscitations
Places of action
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conferencepaper
Inhibition of Candida growth and biofilm formation on polyurethanes by fluconazole adsorption.
Abstract
Recent attempts to prevent device-related infections included several strategies among which catheter coating with antibiotics resulted to be one of the most promising. However, so far only sporadic studies were designed to prevent fungal colonization of devices presumably because of the only recently described ability of Candida species to form biofilms. In this study we report in vitro experiments on the efficacy of coating of newly synthesized polyurethanes with the antifungal drug fluconazole in preventing polymer colonization and biofilm formation by Candida albicans. Polymers used in this study are three synthesized urethane polymers having different functional groups in the side-chain: hydroxyl groups, primary amino groups and tertiary amino groups. Fluconazole was adsorbed on round shaped disks made of the above described polyurethanes. The kinetics of fluconazole release from polymers, either containing or not albumin as pore forming agent, was studied by keeping fluconazole-loaded polymeric disks in water for increasing times up to 8 days. The antifungal activity of polymers was studied by the Kirby Bauer test and scanning electron microscopy. Among the tested polymers, the most hydrophilic ones were able to adsorb higher drug amounts by establishing “hydrogen bond” and “van der Waals” interactions. The kinetics of fluconazole release from polymers was influenced by the degree of polymer swelling in water and resulted significantly improved by the albumin incorporation in polyurethanes which increased polymer porosity. In our best experimental in vitro model consisting of an hydrophilic polymeric disk (average weight 250 mg) impregnated with 62.5mg albumin and 62.5mg fluconazole, the Candida albicans growth was inhibited as evidenced by the Kirby Bauer test and biofilm formation on polymeric surface was not observed up to 8 days as evidenced by scanning electron microscopy. Overall, data obtained from our newly synthesized functionalized polyurethanes loaded with fluconazole seem to be very promising ...