| People | Locations | Statistics |
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| Grohsjean, Alexander |
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| Falmagne, G. |
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| Erice, C. |
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| Hernandez, A. M. Vargas |
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| Leiton, A. G. Stahl |
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| Lipka, K. |
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| Pantaleo, F. |
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| Torterotot, L. |
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| Savina, M. |
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| Cerri, O. |
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| Jung, A. W. |
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| Chiarito, B. |
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| Sahin, M. O. |
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| Strong, G. |
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| Saradhy, R. |
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| Joshi, B. M. |
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| Kaynak, B. |
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| Barrera, C. Baldenegro |
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| Longo, Egidio |
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| Kolberg, Ted |
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| Ferguson, Thomas |
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| Leverington, Blake |
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| Haase, Fabian |
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| Heath, Helen F. |
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| Kokkas, Panagiotis |
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Piozzi, Antonella
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2023Rice husk ash as a green feedstock for the extraction of nano-silica and its application in the synthesis of an efficient solid biocatalyst
- 2020Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocompositescitations
- 2017Taurine grafting and collagen adsorption on PLLA films improve human primary chondrocyte adhesion and growthcitations
- 2016Flexible aliphatic poly(isocyanurate-oxazolidone) resins based on poly(ethylene glycol) diglycidyl ether and 4,4′-methylene dicyclohexyl diisocyanatecitations
- 2015Self-Assembly of catecholic moiety-containing cationic random acrylic copolymerscitations
- 2015Antimicrobial and antioxidant amphiphilic random copolymers to address medical device-centered infectionscitations
- 2014Biomimetic Polyurethanescitations
- 2014Partially sulfonated ethylene-vinyl alcohol copolymer as new substrate for 3,4-ethylenedioxythiophene vapor phase polymerizationcitations
- 2013Editorial of the special issue antimicrobial polymerscitations
- 2012A new approach for the preparation of hydrophilic poly(L-lactide) porous scaffold for tissue engineering by using lamellar single crystalscitations
- 2012Lipase Immobilization on Differently Functionalized Vinyl-Based Amphiphilic Polymers: Influence of Phase Segregation on the Enzyme Hydrolytic Activitycitations
- 2012Synthesis of biomimetic segmented polyurethanes as antifouling biomaterialscitations
- 2010Novel intrinsically antimicrobial polymers to control biofilm formation on medical devices
- 2010Synthesis and properties of block poly(ether-ester)s based on poly(ethylene oxide) and various hydrophobic segmentscitations
- 2010Polyurethane anionomers containing metal ions with antimicrobial properties: Thermal, mechanical and biological characterizationcitations
- 2009Antibiofilm properties of functionalized polyurethanes adsorbed with metal ions (Ag+, Cu2+, Zn2+, Al3+ and Fe3+)
- 2007Synthesis, characterization, and in vitro activity of antibiotic releasing polyurethanes to prevent bacterial resistancecitations
- 2007Staphylococcus epidermidis biofilm growth on polyurethanes is inhibited by the synergistic action of Dispersin B and cefamandole nafate.
- 2005Inhibition of Candida growth and biofilm formation on polyurethanes by fluconazole adsorption.citations
- 2004Inhibition of bacterial biofilm formation on polymer surfaces by a natural antimicrobial agent
- 2004Inhibition of biofilm formation in Gram-positive bacteria by a natural antimicrobial agent
- 2001CATALITIC ACTIVITY OF IMMOBILIZED FUMARASEcitations
- 2000Sulfation and preliminary biological evaluation of ethylene-vinyl alcohol copolymerscitations
Places of action
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article
Self-Assembly of catecholic moiety-containing cationic random acrylic copolymers
Abstract
Amphiphilic polyelectrolytes (APEs), exhibiting particular self-association properties in aqueous media, can be used in different industrial applications, including drug delivery systems. Their typical core-shell structure (micelle) depends on the balance of interactions between hydrophobic and ionizable monomer units. In this work, the structure of amphiphilic cationic random copolymers, obtained by employing different molar ratios of two acrylic monomers, one bearing in the side chain a tertiary amine (N,N-diethylethylendiamine, DED) and the other one a hydrophobic catecholic group (hydroxytyrosol, HTy), was investigated by atomistic molecular dynamics (MD) simulation, 1H NMR analysis, dynamic light scattering (DLS), and zeta potential measurements. The structures of p(AcDED-co-AcHTy) copolymers were compared with that of the cationic homopolymer (pAcDED). MD simulation showed a chain folding in water solution of all polymer materials consistent with the degree of hydrophobicity of the chain, that increases with the number of aromatic residues. This phenomenon was induced by the interaction between the charged amine groups with water and by the associated attraction between aromatic rings inside the molecule. In addition, the p(AcDED-co-AcHTy) 70/30 copolymer had a marked tendency to self-assemble as shown by the radial distribution function among catechol carbon atoms. Electrical conductivity measurements evidenced a micellar arragment for all of the synthesized copolymers, and specially for p(AcDED-co-AcHTy) 70/30, a flower micelle structure seem to be more likely. The stacking interactions among catecholic groups present in the side chain of the copolymers reduced the size and charge density specially for the p(AcDED-co-AcHTy) 70/30 copolymer. Finally, the good antimicrobial activity of all copolymers confirmed the right reached amphiphilic balance. Indeed, a considerable reduction of the minimum inhibitory concentration (from 100 Μg/mL to 40 Μg/mL for pAcDED and p(AcDED-co-AcHTy) 70/30, respectively) was ...