| People | Locations | Statistics |
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| Grohsjean, Alexander |
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| Falmagne, G. |
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| Erice, C. |
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| Hernandez, A. M. Vargas |
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| Leiton, A. G. Stahl |
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| Lipka, K. |
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| Pantaleo, F. |
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| Torterotot, L. |
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| Savina, M. |
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| Cerri, O. |
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| Jung, A. W. |
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| Chiarito, B. |
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| Sahin, M. O. |
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| Strong, G. |
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| Saradhy, R. |
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| Joshi, B. M. |
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| Kaynak, B. |
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| Barrera, C. Baldenegro |
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| Longo, Egidio |
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| Kolberg, Ted |
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| Ferguson, Thomas |
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| Leverington, Blake |
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| Haase, Fabian |
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| Heath, Helen F. |
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| Kokkas, Panagiotis |
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Piozzi, Antonella
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2023Rice husk ash as a green feedstock for the extraction of nano-silica and its application in the synthesis of an efficient solid biocatalyst
- 2020Enhanced performance of Candida rugosa lipase immobilized onto alkyl chain modified-magnetic nanocompositescitations
- 2017Taurine grafting and collagen adsorption on PLLA films improve human primary chondrocyte adhesion and growthcitations
- 2016Flexible aliphatic poly(isocyanurate-oxazolidone) resins based on poly(ethylene glycol) diglycidyl ether and 4,4′-methylene dicyclohexyl diisocyanatecitations
- 2015Self-Assembly of catecholic moiety-containing cationic random acrylic copolymerscitations
- 2015Antimicrobial and antioxidant amphiphilic random copolymers to address medical device-centered infectionscitations
- 2014Biomimetic Polyurethanescitations
- 2014Partially sulfonated ethylene-vinyl alcohol copolymer as new substrate for 3,4-ethylenedioxythiophene vapor phase polymerizationcitations
- 2013Editorial of the special issue antimicrobial polymerscitations
- 2012A new approach for the preparation of hydrophilic poly(L-lactide) porous scaffold for tissue engineering by using lamellar single crystalscitations
- 2012Lipase Immobilization on Differently Functionalized Vinyl-Based Amphiphilic Polymers: Influence of Phase Segregation on the Enzyme Hydrolytic Activitycitations
- 2012Synthesis of biomimetic segmented polyurethanes as antifouling biomaterialscitations
- 2010Novel intrinsically antimicrobial polymers to control biofilm formation on medical devices
- 2010Synthesis and properties of block poly(ether-ester)s based on poly(ethylene oxide) and various hydrophobic segmentscitations
- 2010Polyurethane anionomers containing metal ions with antimicrobial properties: Thermal, mechanical and biological characterizationcitations
- 2009Antibiofilm properties of functionalized polyurethanes adsorbed with metal ions (Ag+, Cu2+, Zn2+, Al3+ and Fe3+)
- 2007Synthesis, characterization, and in vitro activity of antibiotic releasing polyurethanes to prevent bacterial resistancecitations
- 2007Staphylococcus epidermidis biofilm growth on polyurethanes is inhibited by the synergistic action of Dispersin B and cefamandole nafate.
- 2005Inhibition of Candida growth and biofilm formation on polyurethanes by fluconazole adsorption.citations
- 2004Inhibition of bacterial biofilm formation on polymer surfaces by a natural antimicrobial agent
- 2004Inhibition of biofilm formation in Gram-positive bacteria by a natural antimicrobial agent
- 2001CATALITIC ACTIVITY OF IMMOBILIZED FUMARASEcitations
- 2000Sulfation and preliminary biological evaluation of ethylene-vinyl alcohol copolymerscitations
Places of action
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conferencepaper
Inhibition of bacterial biofilm formation on polymer surfaces by a natural antimicrobial agent
Abstract
In modern medicine, medical devices are used for different applications, including the repair or replacement of damaged parts of the body, the delivery of drugs and the monitoring of critically ill patients. However, artificial surfaces are often susceptible to colonization by bacteria and fungi. Once adhered, microrganisms grow forming biofilms and the associated local or systemic infections are highly resistant local or systemic infections. Strategies to prevent these infections include catheter’s coatings with antimicrobials that eluting from the device avoid microbial colonization. Current evidence suggests that (+)-usnic acid, a secondary lichen metabolite, possesses antimicrobial activity against a number of planktonic Gram positive bacteria, including Staphylococcus aureus, Enterococcus faecalis and E. faecium. We evaluated the possible inhibiting effect of usnic acid by loading polymers widely employed to produce several medical devices. As usnic acid exhibits acidic properties, the surface of a polyether urethane acid was specifically modified to introduce basic functional groups (amino groups) able to establish electrostatic interactions with the acidic groups displayed by usnic acid. These functionalised polymers were then incorporated in a flow cell designed for growing biofilms under a wide range of hydrodynamic conditions, and subsequently analysed using confocal microscopy. The capacity of usnic acid to control biofilm formation was assessed using Staphylococcus aureus and the Gram negative pathogen, Pseudomonas aeruginosa. Results: Usnic acid-loaded polymers have been shown to be resistant to biofilm formation by S. aureus and possibly other Gram positive organisms. In contrast, P. aeruginosa biofilm was formed on the surfaces of both the untreated and usnic acid-loaded polymer. However, usnic acid affected the morphology of the P. aeruginosa biofilm, possibly indicating that drug interfered with cell-cell communication by influencing signalling pathways. These promising results open new ...