| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Malcolm, Karl
Queen's University Belfast
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023A multipurpose ‘CZL’ vaginal ring for non-hormonal contraception and STI/HIV prevention
- 2021Custom silicone elastomers for improved mechanical performance and reduced hormone binding in a dapivirine/levonorgestrel vaginal ring
- 2021Preliminary formulation development of silicone elastomer vaginal rings for sustained release of metronidazole, sucrose and lactobacillus
- 2021Formulation development of an ethylene vinyl acetate ring for sustained release of the experimental entry inhibitor DS003
- 2021Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrelcitations
- 2019Dapivirine-releasing vaginal rings produced by plastic freeforming additive manufacturingcitations
- 2019Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTEScitations
- 2019Post-use ring weight, residual drug content and drug depletion zone thickness as objective measures of user adherence to a contraceptive progesterone vaginal ringcitations
- 2019Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomerscitations
- 2019Mechanical testing methods for drug-releasing vaginal ringscitations
- 2019In vitro release testing methods for drug-releasing vaginal ringscitations
- 2018Density Mediated Drug Release From Dapivirine Vaginal Rings Produced by Additive Manufacturing
- 2017Packing polymorphism of dapivirine and its impact on the performance of a dapivirine-releasing silicone elastomer vaginal ringcitations
- 2014Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals
- 2011Dual functional ionic liquids as plasticisers and antimicrobial agents for medical polymerscitations
- 2010Development of liposome-based freeze-dried rods for vaginal vaccine delivery against HIV-1citations
- 2009Persistence of antimicrobial activity through sustained release of triclosan from pegylated silicone elastomerscitations
- 2009Development and evaluation of a vaginal ring device for sustained delivery of HIV microbicides to non-human primate
- 2008The Effect of Tacticity on the Conformational Properties of Poly(1-olefin sulfone)scitations
- 2004Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterialcitations
- 2001Determination of the drug solubility at the melt temperature in silicone intravaginal rings using dynamic mechanical analysis
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document
Custom silicone elastomers for improved mechanical performance and reduced hormone binding in a dapivirine/levonorgestrel vaginal ring
Abstract
Background<br/>We previously reported the chemical binding of levonorgestrel (LNG) to vaginal rings manufactured from addition-cure silicone elastomers. Here, three custom silicones were evaluated for manufacture of a multipurpose technology (MPT) vaginal ring (VR) releasing dapivirine (DPV) and LNG with the aim of reducing LNG binding and improving mechanical performance.<br/> <br/>Methods<br/>Silbione® Biomedical D160 silicone elastomers (Lots 07117-13, 14 and 15) were supplied by Elkem Silicones. Matrix-type VRscontaining 200mg DPV and 320mg non-micronised LNG (nmLNG) were manufactured by injection molding (100°C/95 sec). Elastomer 14 was also used to prepare VRs containing 200mg DPV with 240, 160 or 80mg nmLNG. Various mechanical tests were performed on the VRs and assay values for DPV and LNG were determined. In vitro release testing was performed for the VRs using two different media – IPA:water (1:1 v/v) and sodium acetate buffer with 2% Solutol® HS15.<br/><br/>Results<br/>All three silicones showed similar cure profiles and viscosities conducive to practical ring manufacture and performance (Table 1). <br/><br/>DPV+LNG rings manufactured from Silicone 14 (selected for further study due to its relatively long working time) showed high LNG recovery and good mechanical properties (Table 2).<br/><br/>In vitro DPV release from the Elkem 14 VRs did not change significantly in repsonse to varied nmLNG loading, while LNG release was significantly correlated with initial nmLNG loading.<br/><br/>Conclusion<br/>These new silicone materials, and particularly variation 07117-14, offered desirable mechanical performance and acceptable LNG recovery values for further development of a silicone based MPT ring.<br/>