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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Song, Y.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2021Effect of sub-boundaries on primary spacing dynamics during 3D directional solidification conducted on DECLIC-DSIcitations
- 2018Thermal-field effects on interface dynamics and microstructure selection during alloy directional solidificationcitations
- 2018Enhancement of surface bioactivity on carbon fiber-reinforced polyether ether ketone via graphene modification.citations
- 2017Convection Effects During Bulk Transparent Alloy Solidification in DECLIC-DSI and Phase-Field Simulations in Diffusive Conditionscitations
- 2017Evolution of Primary Spacing during Directional Solidification of Transparent Bulk Samples Conducted on DECLIC-DSI
- 2017Experimental observation of oscillatory cellular patterns in three-dimensional directional solidificationcitations
- 2016Three-dimensional grain boundary instability and solitary cell dynamics in directional solidification of binary alloys
- 2016Phase-field modeling of cellular and dendritic microstructure formation: dynamical selection of the primary spacing
- 2016Dynamics of Microstructure Formation in 3D Directional Solidification of Transparent Model Alloys under Microgravity: Analysis of the Primary Spacing Evolution
- 2016Toughening of carbon fibre reinforced polymer composites with nano rubber for advanced industrial applicationscitations
- 2011Combining stereo and time-of-flight images with application to automatic plant phenotypingcitations
- 2011Combining stereo and time-of-flight images with application to automatic plant phenotypingcitations
- 2005Selective fluorescence detection of divalent and trivalent metal ions with functionalized lipid membranescitations
- 2000Osteogenic protein 1 device stimulates bone healing to hydroxyapaptite-coated and titanium implants
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article
Osteogenic protein 1 device stimulates bone healing to hydroxyapaptite-coated and titanium implants
Abstract
This study evaluated the effects of osteogenic protein 1 (OP-1) placed in a gap around uncoated and hydroxyapatite (HA)-coated implants. Unloaded cylindrical titanium alloy implants were inserted in the femoral condyles of 16 skeletally mature dogs surrounded by a 3-mm gap. The gap around the implants was filled with 325 microg OP-1 in 130 mg bovine collagen type I as carrier (OP-1 device) or collagen carrier alone or left empty. All groups were tested with both HA-coated and uncoated implants, and the animals were sacrificed after 6 weeks. Implant fixation was determined by push-out test. Bone ongrowth and bone formation were evaluated by quantitative histomorphometry. OP-1 device enhanced mechanical fixation of uncoated and HA-coated implants, resulting in a higher shear strength than implants with collagen matrix and control implants. Bone ingrowth and bone formation in the gap were also stimulated 3-fold for OP-1 groups when compared with empty controls, but no difference was found between OP-1 groups and collagen matrix groups. This study suggests that the OP-1 device placed in a gap around uncoated and HA-coated implants is capable of enhancing mechanical fixation and periimplant bone formation. The collagen carrier alone also enhanced bone ongrowth and fixation significantly.