| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Alves, Vítor D.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2024A greener route to prepare PEBAX®1074 membranes for gas separation processescitations
- 2023Chitin-Glucan Complex Hydrogelscitations
- 2023Chitin-Glucan Complex Hydrogels ; Physical-Chemical Characterization, Stability, In Vitro Drug Permeation, and Biological Assessment in Primary Cellscitations
- 2023Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol ; Design, Characterization and Biological Propertiescitations
- 2023Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPolcitations
- 2021Production of medium-chain-length polyhydroxyalkanoates by Pseudomonascitations
- 2021Ionic liquid-based semi-interpenetrating polymer network (sIPN) membranes for CO2 separationcitations
- 2020Low temperature dissolution of yeast Chitin-Glucan complex and characterization of the regenerated polymercitations
- 2019Demonstration of the adhesive properties of the medium-chain-length polyhydroxyalkanoate produced by Pseudomonas chlororaphis subsp. aurantiaca from glycerolcitations
- 2015Conversion of cheese whey into a fucose- and glucuronic acid-rich extracellular polysaccharide by Enterobacter A47citations
- 2011Fucose-containing exopolysaccharide produced by the newly isolated Enterobacter strain A47 DSM 23139citations
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article
Chitin-Glucan Complex Hydrogels
Abstract
<p>Chitin-glucan complex (CGC) hydrogels were fabricated by coagulation of the biopolymer from an aqueous alkaline solution, and their morphology, swelling behavior, mechanical, rheological, and biological properties were studied. In addition, their in vitro drug loading/release ability and permeation through mimic-skin artificial membranes (Strat-M) were assessed. The CGC hydrogels prepared from 4 and 6 wt% CGC suspensions (Na5<sub>1</sub>*<sup>4</sup> and Na5<sub>1</sub>*<sup>6</sup> hydrogels, respectively) had polymer contents of 2.40 ± 0.15 and 3.09 ± 0.22 wt%, respectively, and displayed a highly porous microstructure, characterized by compressive moduli of 39.36 and 47.30 kPa and storage moduli of 523.20 and 7012.25 Pa, respectively. Both hydrogels had a spontaneous and almost immediate swelling in aqueous media, and a high-water retention capacity (>80%), after 30 min incubation at 37 °C. Nevertheless, the Na5<sub>1</sub>*<sup>4</sup> hydrogels had higher fatigue resistance and slightly higher-water retention capacity. These hydrogels were loaded with caffeine, ibuprofen, diclofenac, or salicylic acid, reaching entrapment efficiency values ranging between 13.11 ± 0.49% for caffeine, and 15.15 ± 1.54% for salicylic acid. Similar release profiles in PBS were observed for all tested APIs, comprising an initial fast release followed by a steady slower release. In vitro permeation experiments through Strat-M membranes using Franz diffusion cells showed considerably higher permeation fluxes for caffeine (33.09 µg/cm<sup>2</sup>/h) and salicylic acid (19.53 µg/cm<sup>2</sup>/h), compared to ibuprofen sodium and diclofenac sodium (4.26 and 0.44 µg/cm<sup>2</sup>/h, respectively). Analysis in normal human dermal fibroblasts revealed that CGC hydrogels have no major effects on the viability, migration ability, and morphology of the cells. Given their demonstrated features, CGC hydrogels are very promising structures, displaying tunable physical properties, which support their future development into novel transdermal drug delivery platforms.</p>