| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Katsamenis, Orestis L.
University of Southampton
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 20233D printing of personalised carvedilol tablets using selective laser sinteringcitations
- 2020Fabrication of an osmotic 3D printed solid dosage form for controlled release of active pharmaceutical ingredientscitations
- 2018Controlled release of 5-Fluorouracil from alginate beads encapsulated in 3D printed pH-responsive solid dosage formscitations
- 20173D printed oral solid dosage forms containing hydrochlorothiazide for controlled drug deliverycitations
- 2017Deformation mechanisms of idealised cermets under multi-axial loadingcitations
- 2017Characterization and mapping of rolling contact fatigue in rail-axle bearingscitations
- 20153-D analysis of fatigue crack behaviour in a shot peened steam turbine blade materialcitations
- 2014Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentationcitations
- 2013A novel videography method for generating crack-extension resistance curves in small bone samplescitations
- 2012Mechanism of co-nanoprecipitation of organic actives and block copolymers in a microfluidic environmentcitations
- 2012Bone matrix material properties on the micro- and nanoscale
- 2010Preparation and characterization of bioceramics produced from calcium phosphate cementscitations
Places of action
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article
3D printing of personalised carvedilol tablets using selective laser sintering
Abstract
<p>Selective laser sintering (SLS) has drawn attention for the fabrication of three-dimensional oral dosage forms due to the plurality of drug formulations that can be processed. The aim of this work was to employ SLS with a CO<sub>2</sub> laser for the manufacturing of carvedilol personalised dosage forms of various strengths. Carvedilol (CVD) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64) blends of various ratios were sintered to produce CVD tablets of 3.125, 6.25, and 12.5 mg. The tuning of the SLS processing laser intensity parameter improved printability and impacted the tablet hardness, friability, CVD dissolution rate, and the total amount of drug released. Physicochemical characterization showed the presence of CVD in the amorphous state. X-ray micro-CT analysis demonstrated that the applied CO<sub>2</sub> intensity affected the total tablet porosity, which was reduced with increased laser intensity. The study demonstrated that SLS is a suitable technology for the development of personalised medicines that meet the required specifications and patient needs.</p>