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| Naji, M. |
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| Azevedo, Nuno Monteiro |
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Hassouna, Fatima
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Publications (7/7 displayed)
- 2023Flexible, ultrathin and light films from one-dimensional nanostructures of polypyrrole and cellulose nanofibers for high performance electromagnetic interference shieldingcitations
- 2023Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Predictioncitations
- 2022Tailor-made dual doping for morphology control of polyaniline chains in cellulose nanofiber-based flexible electrodes: electrical and electrochemical performancecitations
- 2021Elaboration and properties of nanofibrillated cellulose composites with polypyrrole nanotubes or their carbonized analogscitations
- 2020New approach for the development of reduced graphene oxide/polyaniline nanocomposites via sacrificial surfactant-stabilized reduced graphene oxidecitations
- 2020Impact of Hot-Melt Extrusion Processing Conditions on Physicochemical Properties of Amorphous Solid Dispersions Containing Thermally Labile Acrylic Copolymercitations
- 2020Temperature modulated polymer nanoparticle bonding: A numerical and experimental studycitations
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article
Solid–Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction
Abstract
<jats:p>In this work, the solid–liquid equilibrium (SLE) of four binary systems combining two active pharmaceutical ingredients (APIs) capable of forming co-amorphous systems (CAMs) was investigated. The binary systems studied were naproxen-indomethacin, naproxen-ibuprofen, naproxen-probucol, and indomethacin-paracetamol. The SLE was experimentally determined by differential scanning calorimetry. The thermograms obtained revealed that all binary mixtures investigated form eutectic systems. Melting of the initial binary crystalline mixtures and subsequent quenching lead to the formation of CAM for all binary systems and most of the compositions studied. The experimentally obtained liquidus and eutectic temperatures were compared to theoretical predictions using the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state and conductor-like screening model for real solvents (COSMO-RS), as implemented in the Amsterdam Modeling Suite (COSMO-RS-AMS). On the basis of the obtained results, the ability of these models to predict the phase diagrams for the investigated API–API binary systems was evaluated. Furthermore, the glass transition temperature (Tg) of naproxen (NAP), a compound with a high tendency to recrystallize, whose literature values are considerably scattered, was newly determined by measuring and modeling the Tg values of binary mixtures in which amorphous NAP was stabilized. Based on this analysis, erroneous literature values were identified.</jats:p>