• Ikram, Muhammad
• Medina, Francisco
• Butt, Alvina Rafiq
• Haider, Ali
• Atiq, Iram
• Ul-Hamid, Anwar
• Nabgan, Walid

Abstract

<jats:p>In this study, MoO<jats:sub>3</jats:sub> nanostructures were prepared, doped with various concentrations of graphene oxide (2 and 4% GO) and a fixed amount of polyvinylpyrrolidone (PVP) using the co-precipitation method. The motive of this study was to examine the catalytic and antimicrobial efficacy with evidential molecular docking analyses of GO/PVP-doped MoO<jats:sub>3</jats:sub>. GO and PVP were utilized as doping agents to reduce the exciton recombination rate of MoO<jats:sub>3</jats:sub> by providing more active sites that increase the antibacterial activity of MoO<jats:sub>3</jats:sub>. The prepared binary dopant (GO and PVP)-dependent MoO<jats:sub>3</jats:sub> was used as an effective antibacterial agent against <jats:italic>Escherichia coli</jats:italic> (<jats:italic>E. coli</jats:italic>). Notably, 4% GO/PVP-doped MoO<jats:sub>3</jats:sub> showed good bactericidal potential against <jats:italic>E. coli</jats:italic> at higher concentrations in comparison to ciprofloxacin. Furthermore, <jats:italic>in silico</jats:italic> docking revealed the possible inhibitory impact of the synthesized nanocomposites on folate and fatty acid synthesis enzymes, dihydrofolate reductase and enoyl-[acyl carrier protein] reductase, respectively.</jats:p>

Topics

• nanocomposite
• precipitation